ESR2 anticorps (AA 1-153)

N° du produit ABIN189996

Cet anticorps anti-ESR2 Monoclonal Souris (Clone 6A12) (ABIN189996) détecte spécifiquement ESR2 dans WB, IHC, IF/ICC et ChIP. L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour ESR2 anticorps (AA 1-153) (ABIN189996)

Antigène: ESR2 (Estrogen Receptor 2 (ESR2))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp ESR2 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (fixed cells) (IF/ICC), Chromatin Immunoprecipitation (ChIP)

Clone: 6A12

Détail du produit anti-ESR2 anticorps

Épitope: AA 1-153

Fonction: Anti-Estrogen Receptor beta Mouse Monoclonal Antibody

Specificité: This antibody recognizes human ER-b, a novel receptor (approx. 52 kD) recently isolated from testis. The size and structure of ER-b are very similar to ER-alpha with the ligand and DNA binding domains being highly conserved. The N-terminus of each receptor, which serves as their transactivation domain, are significantly different. Like ER-alpha, ER-b binds to estrogen with a high affinity and regulates estrogen-specific gene activation through direct interaction with estrogen response elements.

Réactivité croisée: Humain

Immunogène: 6-His fusion protein containing the region encoding aa 1-153 of human estrogen receptor-b (ER-b) expressed in E. coli.

Isotype: IgG2b

Information d'application

Indications d'application: Immunoblotting: use at 1-5 μg/mL.
Positive controls: Native receptor from human thymus, spleen, ovary, and testis or recombinant protein.

Restrictions: For Research Use only

Stockage

Format: Liquid

Reconstitution: Dilute in PBS or medium which is identical to that used in the assay system.

Concentration: Lot specific

Buffer: PBS, pH 7.4

Stock: -80 °C

Stockage commentaire: This antibody is stable for at least one (1) year at -70°C. Avoid multiple freeze- thaw cycles.

Détails sur ESR2

Antigène: ESR2 (Estrogen Receptor 2 (ESR2))

Autre désignation: Estrogen receptor beta

Sujet: Estrogen receptor beta,Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1/ER-alpha, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner (PubMed:20074560). {PubMed:20074560, PubMed:29261182, PubMed:30113650, PubMed:9325313}., [Isoform 2]: Lacks ligand binding ability and has no or only very low ERE binding activity resulting in the loss of ligand-dependent transactivation ability. {PubMed:9671811}.,Nucleus,ER-beta, Nuclear receptor subfamily 3 group A member 2

ID gène: 2100

NCBI Accession: NP_001035365

UniProt: Q92731

Pathways: Nuclear Receptor Transcription Pathway, EGFR Signaling Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Steroid Hormone Mediated Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling