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NUMBL anticorps (C-Term)

NUMBL Reactivité: Humain WB, IHC (p) Hôte: Lapin Polyclonal RB34676 unconjugated
N° du produit ABIN658002
  • Antigène Voir toutes NUMBL Anticorps
    NUMBL (Numb Homolog (Drosophila)-Like (NUMBL))
    Épitope
    • 15
    • 8
    • 6
    • 5
    • 4
    • 2
    • 1
    • 1
    AA 572-600, C-Term
    Reactivité
    • 46
    • 9
    • 9
    • 1
    Humain
    Hôte
    • 44
    • 1
    • 1
    Lapin
    Clonalité
    • 45
    • 1
    Polyclonal
    Conjugué
    • 11
    • 5
    • 5
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp NUMBL est non-conjugé
    Application
    • 31
    • 22
    • 16
    • 13
    • 13
    • 4
    • 4
    • 3
    • 3
    • 2
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Purification
    This antibody is purified through a protein A column, followed by peptide affinity purification.
    Immunogène
    This NUMBL antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 572-600 amino acids from the C-terminal region of human NUMBL.
    Clone
    RB34676
    Isotype
    Ig Fraction
    Top Product
    Discover our top product NUMBL Anticorps primaire
  • Indications d'application
    WB: 1:1000. IHC-P: 1:10~50
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C,-20 °C
    Stockage commentaire
    NUMBL Antibody (C-term) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.
    Date de péremption
    6 months
  • Antigène
    NUMBL (Numb Homolog (Drosophila)-Like (NUMBL))
    Autre désignation
    NUMBL (NUMBL Produits)
    Synonymes
    anticorps nbl, anticorps numb, anticorps cag3a, anticorps ctg3a, anticorps numbr, anticorps numb-r, anticorps tnrc23, anticorps numblike, anticorps CAG3A, anticorps CTG3a, anticorps NBL, anticorps NUMB-R, anticorps NUMBLIKE, anticorps NUMBR, anticorps TNRC23, anticorps NUMB like, endocytic adaptor protein, anticorps numb homolog-like L homeolog, anticorps NUMB-like, endocytic adaptor protein, anticorps numb-like, anticorps NUMBL, anticorps numbl.L, anticorps Numbl
    Sujet
    NUMBL plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of embryonic neurogenesis. Also required postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. Negative regulator of NF-kappa-B signaling pathway. The inhibition of NF-kappa-B activation is mediated at least in part, by preventing MAP3K7IP2 to interact with polyubiquitin chains of TRAF6 and RIPK1 and by stimulating the 'Lys-48'-linked polyubiquitination and degradation of TRAF6 in cortical neurons.
    Poids moléculaire
    64891
    ID gène
    9253
    NCBI Accession
    NP_004747
    UniProt
    Q9Y6R0
    Pathways
    Cell-Cell Junction Organization
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