Aldehyde Dehydrogenase 2 Family (Mitochondrial) (ALDH2) anticorps

Détails pour le produit réf. ABIN658993, Fournisseur: Connectez-vous pour afficher
Antigène
  • aldh2
  • aldh2a
  • zgc:63786
  • MGC80785
  • aldh-e2
  • aldhi
  • aldm
  • rf2b
  • ALDH-E2
  • ALDHI
  • ALDM
  • Ahd-5
  • Ahd5
  • aldehyde dehydrogenase 2 family (mitochondrial), tandem duplicate 1
  • aldehyde dehydrogenase 2 family (mitochondrial) L homeolog
  • aldehyde dehydrogenase 2 family (mitochondrial)
  • aldehyde dehydrogenase 2
  • aldehyde dehydrogenase
  • aldehyde dehydrogenase (NAD(+))
  • hypothetical protein
  • aldehyde dehydrogenase 2, mitochondrial
  • aldh2.1
  • aldh2.L
  • aldh2
  • ALDH2
  • RHA1_RS43090
  • aldH2
  • OE_RS03015
  • Aldh2
Reactivité
Humain
176
54
53
4
4
3
3
2
1
1
1
1
Hôte
Souris
112
51
18
Clonalité (Clone)
Monoclonal ()
Conjugué
Inconjugué
10
7
6
6
6
6
Application
Flow Cytometry (FACS), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
172
93
91
43
39
32
14
11
9
7
1
Options
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Immunogène This ALDH2 Monoclonal antibody is generated from mouse immunized with ALDH2 recombinant protein.
Clone 138CT22-3-8
Isotype IgG1, Ig
Specificité This ALDH2 Monoclonal antibody is generated from mouse immunized with ALDH2 recombinant protein.
Purification This antibody is purified through a protein G column, followed by dialysis against PBS.
Antigène
Autre désignation ALDH2 (ALDH2 Antibody Extrait)
Sujet This protein belongs to the aldehyde dehydrogenase family of proteins. Aldehyde dehydrogenase is the second enzyme of the major oxidative pathway of alcohol metabolism. Two major liver isoforms of this enzyme, cytosolic and mitochondrial, can be distinguished by their electrophoretic mobilities, kinetic properties, and subcellular localizations. Most Caucasians have two major isozymes, while approximately 50% of Orientals have only the cytosolic isozyme, missing the mitochondrial isozyme. A remarkably higher frequency of acute alcohol intoxication among Orientals than among Caucasians could be related to the absence of the mitochondrial isozyme. This gene encodes a mitochondrial isoform, which has a low Km for acetaldehydes, and is localized in mitochondrial matrix.
Synonyms: ALDH-E2, ALDHI, ALDH class 2, Aldehyde dehydrogenase, mitochondrial,ALDM, ALDH2
Pathways: Glycolysis / Gluconeogenesis, Pyruvate metabolism, Fatty acid metabolism, Glycerolipid metabolism, Histidine metabolism, beta-Alanine metabolism, Arginine and proline metabolism, Valine, leucine and isoleucine degradation, Tryptophan metabolism
Poids moléculaire 56381 Da
ID gène 217
UniProt P05091
Indications d'application WB = 1:100-1000, IHC (p) = 1:50-100, FACS = 1:10-50, IF = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Agent conservateur Sodium azide
Précaution d'utilisation This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Stock 4 °C/-20 °C
Stockage commentaire Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Date de péremption 6 months
Images (Fournisseur)
Western Blotting (WB) image for anti-Aldehyde Dehydrogenase 2 Family (Mitochondrial) (ALDH2) antibody (ABIN658993) Western blot analysis of ALDH2 monoclonal antibody in HepG2 cell line lysates (35ug/...
Immunohistochemistry (IHC) image for anti-Aldehyde Dehydrogenase 2 Family (Mitochondrial) (ALDH2) antibody (ABIN658993) ALDH2 Monoclonal Antibody immunohistochemistry analysis in formalin fixed and paraff...
Flow Cytometry (FACS) image for anti-Aldehyde Dehydrogenase 2 Family (Mitochondrial) (ALDH2) antibody (ABIN658993) ALDH2 Monoclonal Antibody flow cytometric analysis of HepG2 cells (right histogram) ...
Immunofluorescence (IF) image for anti-Aldehyde Dehydrogenase 2 Family (Mitochondrial) (ALDH2) antibody (ABIN658993) Confocal immunofluorescent analysis of ALDH2 Antibody with HepG2 cell followed by Al...
Background publications Yang, Yokoyama, Yokoyama, Huang, Wu, Shao, Niu, Wang, Liu, Zhou, Yang: "Relationship between genetic polymorphisms of ALDH2 and ADH1B and esophageal cancer risk: a meta-analysis." dans: World journal of gastroenterology : WJG, Vol. 16, Issue 33, pp. 4210-20, 2010 (PubMed).

Weng, Weng, Lu, Nakayama, Morimoto: "Effects of alcohol-drinking behaviour and ADH1B and ALDH2 polymorphisms on basal DNA damage in human mononuclear cells as determined by the comet assay." dans: Mutation research, Vol. 701, Issue 2, pp. 132-6, 2010 (PubMed).

Hendershot, Otto, Collins, Liang, Wall: "Evaluation of a brief web-based genetic feedback intervention for reducing alcohol-related health risks associated with ALDH2." dans: Annals of behavioral medicine : a publication of the Society of Behavioral Medicine, Vol. 40, Issue 1, pp. 77-88, 2010 (PubMed).

Zhou, Diao, Li, Li, Ma, Cui: "Association of genetic polymorphisms of aldehyde dehydrogenase-2 with esophageal squamous cell dysplasia." dans: World journal of gastroenterology : WJG, Vol. 16, Issue 27, pp. 3445-9, 2010 (PubMed).

Bailey, Xie, Do, Montpetit, Diaz, Mohan, Keavney, Yusuf, Gerstein, Engert, Anand: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." dans: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, 2010 (PubMed).

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