Cathepsin K anticorps (AA 163-274)

N° du produit ABIN6654326

Cet anticorps anti-Cathepsin K Monoclonal Souris (Clone CTSK-2791) (ABIN6654326) détecte spécifiquement Cathepsin K dans IHC (p). L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour Cathepsin K anticorps (AA 163-274) (ABIN6654326)

Antigène: Cathepsin K (CTSK)

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Cathepsin K est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: CTSK-2791

Détail du produit anti-Cathepsin K anticorps

Épitope: AA 163-274

Fonction: Cathepsin K Antibody / CTSK

Purification: Protein G affinity chromatography

Immunogène: A portion of amino acids 163-274 from the human protein was used as the immunogen for the Cathepsin K antibody.

Isotype: IgG1, kappa

Information d'application

Indications d'application: Optimal dilution of the Cathepsin K antibody to be determined by the researcher.

1. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store the Cathepsin K antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Détails sur Cathepsin K

Antigène: Cathepsin K (CTSK)

Autre désignation: Cathepsin K

Sujet: The protein encoded by this gene is a lysosomal cysteine proteinase involved in bone remodeling and resorption. This protein, which is a member of the peptidase C1 protein family, is predominantly expressed in osteoclasts. However, the encoded protein is also expressed in a significant fraction of human breast cancers, where it could contribute to tumor invasiveness. Mutations in this gene are the cause of pycnodysostosis, an autosomal recessive disease characterized by osteosclerosis and short stature.

UniProt: P43235

Pathways: Activation of Innate immune Response, Toll-Like Receptors Cascades