Recombinant ANO1 anticorps (AA 2-101)

N° du produit ABIN6654568

L’anticorps anti-ANO1 Monoclonal Lapin est utilisé pour la détection de ANO1 dans des échantillons de Humain. Il a été validé pour IHC (p).

Aperçu rapide pour Recombinant ANO1 anticorps (AA 2-101) (ABIN6654568)

Antigène: ANO1 (Anoctamin 1, Calcium Activated Chloride Channel (ANO1))

Type d'anticorp: Recombinant Antibody

Reactivité: Humain

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp ANO1 est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Classe de qualité: Carrier-free

Clone: DG1-2564R

Détail du produit anti-ANO1 anticorps

Épitope: AA 2-101

Fonction: Recombinant DOG1 Antibody (azide and preservative free)

Purification: Protein A affinity chromatography

Immunogène: A portion of amino acids 2-101 from the human protein was used as the immunogen for this recombinant DOG1 antibody.

Isotype: IgG, kappa

Information d'application

Indications d'application: The concentration stated for each application is a general starting point. Variations in protocols, secondaries and substrates may require the recombinant DOG1 antibody to be titered up or down for optimal performance.

1. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Agent conservateur: Azide free

Stock: 4 °C,-20 °C

Stockage commentaire: Store the recombinant DOG1 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Détails sur ANO1

Antigène: ANO1 (Anoctamin 1, Calcium Activated Chloride Channel (ANO1))

Autre désignation: DOG1

Sujet: Expression of DOG-1 protein is elevated in the gastrointestinal stromal tumors (GIST's), c-kit signaling-driven mesenchymal tumors of the GI tract. DOG-1 is rarely expressed in other soft tissue tumors, which, due to appearance, may be difficult to diagnose. Immunoreactivity for DOG-1 has been reported in 97.8 percent of scorable GIST's, including all c-kit negative GIST's. Overexpression of DOG-1 has been suggested to aid in the identification of GISTs, including Platelet-Derived Growth Factor Receptor Alpha mutants that fail to express c-kit antigen. The overall sensitivity of DOG1 and c-kit in GIST's is nearly identical: 94.4 % vs. 94.7 %.

UniProt: Q5XXA6