p63 anticorps

N° du produit ABIN6655001

Cet anticorps anti-p63 est un anticorps Souris Monoclonal détectant p63 dans IHC (p). Adapté pour Humain et Souris.

Aperçu rapide pour p63 anticorps (ABIN6655001)

Antigène: p63 (TP63) (Tumor Protein P63 (TP63))

Reactivité: Humain, Souris

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp p63 est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: TP63-11

Détail du produit anti-p63 anticorps

Purification: Purified

Pureté: Protein G affinity chromatography

Immunogène: Full length human recombinant protein was used as the immunogen for the p63 antibody.

Isotype: IgG2a

Information d'application

Indications d'application: Optimal dilution of the p63 antibody should be determined by the researcher.

1. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.\. Immunohistochemistry (FFPE): 0.25-0.5 μg/mL for 30 min at RT,Prediluted IHC only format : incubate for 30 min at RT (1)

Restrictions: For Research Use only

Stockage

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Agent conservateur: Azide free

Stock: 4 °C,-20 °C

Stockage commentaire: Store the p63 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide).

Détails sur p63

Antigène: p63 (TP63) (Tumor Protein P63 (TP63))

Autre désignation: p63 / Tumor protein 63

Sujet: P63 is a homolog of the tumor suppressor p53. It is identified in basal cells in the epithelial layers of a variety of tissues, including epidermis, cervix, urothelium, breast and prostate. p63 was detected in nuclei of the basal epithelium in normal prostate glands, however, it was not expressed in malignant tumors of the prostate. As a result, p63 has been reported as a useful marker for differentiating benign from malignant lesions in the prostate, particularly when used in combination with markers of high molecular weight cytokeratins and the prostate-specific marker AMACR (P504S). p63 has also been shown to be a sensitive marker for lung squamous cell carcinomas (SqCC), with a sensitivity of ~90 % . Specificity for lung SqCC, vs. lung adenocarcinoma (LADC), is approximately 80 %. In breast tissue, p63 has been identified in myoepithelial cells of normal ducts.