ABCA4 anticorps

N° du produit ABIN6655047

N° du produit (Fournisseur): 200-301-d05

Cet anticorps Souris Monoclonal détecte spécifiquement ABCA4 dans WB, IHC et ELISA. Il présente une réactivité envers Boeuf (Vache) et a été mentionné dans 1 publication.

Aperçu rapide pour ABCA4 anticorps (ABIN6655047)

Antigène: ABCA4 (ATP-Binding Cassette, Sub-Family A (ABC1), Member 4 (ABCA4))

Reactivité: Boeuf (Vache)

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp ABCA4 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Clone: 3F4

Détail du produit anti-ABCA4 anticorps

N° du produit (Fournisseur): 200-301-d05

Fournisseur: Rockland

Fonction: ABCA4 Rim Protein Antibody

Réactivité croisée (Details): Anti-ABCA4 antibody is directed against bovine ABCA4 Rim Protein.

Purification: The antibody was Protein G purified from culture supernatant.

Immunogène: Anti-ABCA4 antibody was produced by repeated immunizations with 220-kDa (full length) partially purified native bovine disc rim protein.

Isotype: IgG

Information d'application

Indications d'application:

ELISA_Dilution: 1:10,000

Immunohistochemistry_Dilution: 1:100

Western_Blot_Dilution: 1:1000

Commentaires:

Suggested Applications: IF
Anti-ABCA4 antibody has been tested by western blot and IHC and is suitable for use in ELISA. Specific conditions should be optimized by the end user. Expect a band of ~220kDa in size corresponding to ABCA4 proteins in the appropriate cell lysate or extract.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer:

Buffer: 0.01 M HEPES, 0.15 M Sodium Chloride, pH 7.5

Stabilizer: 0.1 mg/mL Bovine Serum Albumin (BSA) - IgG and Protease free, 50 % (v/v) Glycerol

Stock: 4 °C,-20 °C

Stockage commentaire: Store vial at -20° C prior to opening.  This product is stable at 4° C as an undiluted liquid.  For extended storage, aliquot contents and freeze at -20° C or below.  Avoid cycles of freezing and thawing. Dilute only prior to immediate use.

Date de péremption: 12 months

Références pour anticorps anti-ABCA4 (ABIN6655047)

Cowan, Renner, De Gennaro, Gross-Scherf, Goldblum, Hou, Munz, Rodrigues, Krol, Szikra, Cuttat, Waldt, Papasaikas, Diggelmann, Patino-Alvarez, Galliker, Spirig, Pavlinic, Gerber-Hollbach, Schuierer, Srdanovic, Balogh, Panero, Kusnyerik, Szabo, Stadler, Org: "Cell Types of the Human Retina and Its Organoids at Single-Cell Resolution." dans: Cell, Vol. 182, Issue 6, pp. 1623-1640.e34, (2021) (PubMed).

Détails sur ABCA4

Antigène: ABCA4 (ATP-Binding Cassette, Sub-Family A (ABC1), Member 4 (ABCA4))

Autre désignation: ABCA4 Rim Protein

Sujet:

Synonyms: Retinal-specific ATP-binding cassette transporter, ATP-binding cassette sub-family A member 4, RIM ABC transporter

Background: ABCA4 antibody detects ABCA4 (ATP-binding cassette, sub-family A (ABC1), member 4, Rim Protein) a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABCA4 is a retina-specific ABC transporter with N-retinylidene-PE as a substrate. It is expressed exclusively in retina photoreceptor cells, indicating the gene product mediates transport of an essential molecule across the photoreceptor cell membrane. Mutations in this gene are found in patients diagnosed with Stargardt disease and are associated with retinitis pigmentosa-19 and age-related macular degeneration. Defects in ABCA4 are the cause of Stargardt disease type 1 (STGD1). STGD is one of the most frequent causes of macular degeneration in childhood. Defects in ABCA4 are also known to cause fundus flavimaculatus (FFM), age-related macular degeneration type 2 (ARMD2) and cone-rod dystrophy type 3 (CORD3). Anti-ABCA4 antibody is ideal for investigators involved in Cell Signaling, Neuroscience, Signal Transduction research.

Gene Name: ABCA4

ID gène: 11304

NCBI Accession: NP_776646

UniProt: O35600