GFAP anticorps

N° du produit ABIN6655052

N° du produit (Fournisseur): 100-401-d60

Cet anticorps anti-GFAP est un anticorps Lapin Polyclonal détectant GFAP dans WB, IHC et FM. Adapté pour Boeuf (Vache). Ce Primary Antibody a été cité dans 1 publication.

Aperçu rapide pour GFAP anticorps (ABIN6655052)

Antigène: GFAP (Glial Fibrillary Acidic Protein (GFAP))

Reactivité: Boeuf (Vache)

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp GFAP est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Fluorescence Microscopy (FM)

Détail du produit anti-GFAP anticorps

N° du produit (Fournisseur): 100-401-d60

Fournisseur: Rockland

Fonction: Glial Fibrillary Acidic Protein (GFAP) Antibody

Réactivité croisée (Details): The antibody is directed against bovine glial fibrillary acidic proteins.

Purification: Anti-GFAP antibody was prepared from monospecifc neat serum.

Immunogène: Anti-GFAP Antibody was produced in rabbit by repeated immunizations with recombinant and purified bovine glial fibrillary acidic protein.

Isotype: IgG

Information d'application

Indications d'application:

IF_Microscopy_Dilution: 1:1000

Western_Blot_Dilution: 1:1000

Commentaires:

Anti-Glial Fibrillary Acidic Protein (Rabbit) antibody has been tested by western blot, ICC, and IHC and is suitable for use in IF. Anti-Glial Fibrillary Acidic Protein antibodies are specific for the ~50kDa GFAP protein. A lower band at ~45kDa is a proteolytic fragment derived from the GFAP molecule. Specific conditions for reactivity should be optimized by the end user.

Restrictions: For Research Use only

Stockage

Format: Liquid

Stock: 4 °C,-20 °C

Stockage commentaire: Store vial at -20° C prior to opening.  This product is stable at 4° C as an undiluted liquid.  For extended storage, aliquot contents and freeze at -20° C or below.  Avoid cycles of freezing and thawing. Dilute only prior to immediate use.

Date de péremption: 12 months

Références pour anticorps anti-GFAP (ABIN6655052)

Qin, Buckley, Li, Liu, Fox, Meares, Yu, Yan, Harms, Li, Standaert, Benveniste: "Inhibition of the JAK/STAT Pathway Protects Against α-Synuclein-Induced Neuroinflammation and Dopaminergic Neurodegeneration." dans: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 36, Issue 18, pp. 5144-59, (2017) (PubMed).

Détails sur GFAP

Antigène: GFAP (Glial Fibrillary Acidic Protein (GFAP))

Sujet:

Synonyms: gfapl, DKFZp459C0729, MGC139638, FLJ45472, AI836096, cb345.

Background: Glial Fibrillary Acidic Protein (GFAP) was discovered by Amico Bignami and co-workers as a major fibrous protein of multiple sclerosis plaques. It was subsequently found to be a member of the 10nm or intermediate filament (IF) family, specifically the IF family Class III, which also includes peripherin, desmin and vimentin. GFAP is strongly and specifically expressed in astrocytes and certain other astroglia in the CNS, in satellite cells, peripheral ganglia, and in non-myelinating Schwann cells in peripheral nerves. In many damage and disease states GFAP expression is heavily upregulated in astrocytes. In addition, neural stem cells frequently strongly express GFAP. Point mutations in the protein coding region of the GFAP gene lead to Alexander disease which is characterized by the presence of abnormal astrocytes containing GFAP protein aggregates known as Rosenthal fibers. Therefore, GFAP antibody is ideal for investigators involved in neuropathologic diseases and more generally in Neuroscience.

Gene Name: GFAP

ID gène: 281189

UniProt: Q28115