Androgen Receptor anticorps (pSer94)

N° du produit ABIN6655077

N° du produit (Fournisseur): 600-401-w93

Cet anticorps Lapin Polyclonal détecte spécifiquement Androgen Receptor dans WB et ELISA. Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour Androgen Receptor anticorps (pSer94) (ABIN6655077)

Antigène: Androgen Receptor (AR)

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Androgen Receptor est non-conjugé

Application: Western Blotting (WB), ELISA

Détail du produit anti-Androgen Receptor anticorps

Épitope: pSer94

N° du produit (Fournisseur): 600-401-w93

Fournisseur: Rockland

Fonction: Androgen Receptor phospho S94 Antibody

Réactivité croisée (Details): This antibody is specific for phosphorylated Androgen Receptor.

Purification: Anti-Phospho-Ser94 Androgen Receptor Antibody was prepared from monospecific antiserum by immunoaffinity chromatography using phospho peptide coupled to agarose beads followed by solid phase adsorption(s) against non-phospho peptide and non-specific peptide to remove any unwanted reactivities.

Stérilité: Sterile filtered

Immunogène: Anti-Phospho-Ser94 Androgen Receptor Antibody was produced in rabbits by repeated immunizations with a synthetic phospho-peptide corresponding to amino acid residues surrounding the phosphorylated Ser94 of human AR conjugated to KLH.

Isotype: IgG

Information d'application

Indications d'application:

ELISA_Dilution: 1:10,000

Western_Blot_Dilution: 1:1000

Commentaires:

Anti-Phospho-Ser94 Androgen Receptor Antibody is tested for Western blots. Expect a band at approximately ~110 kDa on specific lysates or tissues. Specific conditions for reactivity should be optimized by the end user.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer:

Buffer: 0.01 M HEPES, 0.15 M Sodium Chloride, pH 7.5

Stabilizer: 0.1 mg/mL Bovine Serum Albumin (BSA) - IgG and Protease free, 50 % (v/v) Glycerol

Preservative: None

Agent conservateur: Without preservative

Stock: -20 °C

Stockage commentaire: Store vial at -20° C prior to opening in undiluted aliquots. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. Dilute only prior to immediate use.

Date de péremption: 12 months

Détails sur Androgen Receptor

Antigène: Androgen Receptor (AR)

Autre désignation: Androgen Receptor

Sujet:

Synonyms: Dihydrotestosterone receptor, Nuclear receptor subfamily 3 group C member 4

Background: The androgen receptor (AR) is a DNA-binding transcription factor that regulates genes critical for the development and maintenance of the male sexual phenotype. Defects in androgen receptor have been shown to play a role in prostate cancer, and inhibition of AR activity through modulation of signal transduction pathways may delay prostate cancer progression. Multiple phosphorylation sites have been identified on the androgen receptor that affect cross-talk between growth factor signaling and androgen in prostate development and cancer. One of these sites, at Ser94, appears constitutively phosphorylated and exhibits no response to treatments with stimulating hormone. The site at Ser94 is unique among the AR phosphorylation sites in that it does not achieve a maximal level of phosphorylation between translation and the initial round of nuclear import, having a strong bias for androgen-independent phosphorylation in the cytoplasm. Androgen Receptor pS94 Antibody is ideal for researchers interested in cancer research.

Gene Name: AR

ID gène: 367

NCBI Accession: NP_001011645

UniProt: P10275

Pathways: Nuclear Receptor Transcription Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Steroid Hormone Mediated Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Nuclear Hormone Receptor Binding, Chromatin Binding