THRB anticorps (N-Term)

N° du produit ABIN6655581

N° du produit (Fournisseur): 209-301-a96

Cet anticorps Souris Monoclonal détecte spécifiquement THRB dans WB. Il présente une réactivité envers Humain et a été mentionné dans 2+ publications.

Aperçu rapide pour THRB anticorps (N-Term) (ABIN6655581)

Antigène: THRB (Thyroid Hormone Receptor, beta (THRB))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp THRB est non-conjugé

Application: Western Blotting (WB)

Clone: 2386

Détail du produit anti-THRB anticorps

Épitope: N-Term

N° du produit (Fournisseur): 209-301-a96

Fournisseur: Rockland

Fonction: Thyroid Hormone Receptor beta Antibody

Réactivité croisée (Details): Thyroid Hormone Receptor beta antibody is purified by Protein G chromatography from cell culture supernatant.

Purification: Anti-Thyroid Hormone Receptor beta antibody is directed against human TRβ.

Immunogène: Anti-Thyroid Hormone Receptor beta monoclonal antibody was produced in mouse by repeated immunizations with synthetic peptide corresponding to amino acid residues from the N-terminal region of Thyroid Hormone Receptor beta.

Isotype: IgG1

Information d'application

Indications d'application: Optional[Neutralization_Dilution]: 1:1000

Commentaires:

Suggested Applications: IHC
Anti-Thyroid Hormone Receptor beta (Mouse) antibody is tested for use in Western Blotting. Expect a band of approximately 55 kDa corresponding to TR-β proteins in the appropriate cell lysate or extract. Researchers should determine optimal titers for applications that are not stated below.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer:

Buffer: 0.01 M HEPES, 0.15 M Sodium Chloride, pH 7.5

Stabilizer: 0.1 mg/mL Bovine Serum Albumin (BSA) - IgG and Protease free, 50 % (v/v) Glycerol

Stock: 4 °C,-20 °C

Stockage commentaire: Store vial at -20° C prior to opening.  This product is stable at 4° C as an undiluted liquid.  For extended storage, aliquot contents and freeze at -20° C or below.  Avoid cycles of freezing and thawing. Dilute only prior to immediate use.

Date de péremption: 12 months

Références pour anticorps anti-THRB (ABIN6655581)

Aksoy, Pencik, Hartenbach, Moazzami, Schlederer, Balber, Varady, Philippe, Baltzer, Mazumder, Whitchurch, Roberts, Haitel, Herac, Susani, Mitterhauser, Marculescu, Stangl-Kremser, Hassler, Kramer, Shariat, Turner, Tichy, Oppelt, Pospisilova, Hartenbach, T: "Thyroid and androgen receptor signaling are antagonized by μ-Crystallin in prostate cancer." dans: International journal of cancer, Vol. 148, Issue 3, pp. 731-747, (2021) (PubMed).

Schnoell, Kotowski, Jank, Stoiber, Gurnhofer, Schlederer, Heiduschka, Kenner, Kadletz-Wanke: "Prognostic Relevance of Thyroid-Hormone-Associated Proteins in Adenoid Cystic Carcinoma of the Head and Neck." dans: Journal of personalized medicine, Vol. 11, Issue 12, (2021) (PubMed).

Détails sur THRB

Antigène: THRB (Thyroid Hormone Receptor, beta (THRB))

Autre désignation: Thyroid Hormone Receptor beta

Sujet:

Synonyms: mouse anti-Thyroid Hormone Receptor beta Antibody, mouse anti-Thrb antibody, Nuclear receptor subfamily 1 group A member 2, c-erbA-2, c-erbA-beta

Background: Thyroid Hormone Receptor beta antibody detects Thyroid Hormone Receptor beta. Thyroid hormones are essential for development of the central nervous system and deficits in these hormones during development affects such cognitive functions as learning and memory. Thyroid hormones exert their physiological role mainly through binding to specific nuclear receptors including the predominant isoforms of thyroid hormone receptors TRα1, TRα2, TRβ1 and TRβ2. TRα1, TRβ1 and TRβ2 bind T3 with high affinity and also bind to thyroid hormone response elements (TREs) on chromatin to regulate the transcriptional processes in several target tissues, including adult rat brain. Thyroid Hormone Receptor beta antibody is ideal for investigators involved in Cell Signaling, Neuroscience, Signal Transduction research.

Gene Name: THRB

ID gène: 7068

NCBI Accession: NP_000452

UniProt: P10828

Pathways: Nuclear Receptor Transcription Pathway, Steroid Hormone Mediated Signaling Pathway, Sensory Perception of Sound