DGCR8 anticorps (pSer377)

N° du produit ABIN6655713

N° du produit (Fournisseur): 600-401-x01

Cet anticorps Lapin Polyclonal détecte spécifiquement DGCR8 dans WB et ELISA. Il présente une réactivité envers Humain.

Aperçu rapide pour DGCR8 anticorps (pSer377) (ABIN6655713)

Antigène: DGCR8 (DiGeorge Syndrome Critical Region Gene 8 (DGCR8))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp DGCR8 est non-conjugé

Application: Western Blotting (WB), ELISA

Détail du produit anti-DGCR8 anticorps

Épitope: pSer377

N° du produit (Fournisseur): 600-401-x01

Fournisseur: Rockland

Fonction: DGCR8 Phospho S377 Antibody

Purification: Anti-Phospho-Ser377 DGCR8 Antibody was prepared from rabbit serum by affinity purification via sequential chromatography on phospho- and dephosphopeptide affinity columns.

Stérilité: Sterile filtered

Immunogène: Anti-Phospho-Ser377 DGCR8 Antibody was produced in rabbits by repeated immunizations with a synthetic phospho-peptide corresponding to amino acid residues surrounding Ser377 of human DGCR8 conjugated to KLH.

Isotype: IgG

Information d'application

Indications d'application:

ELISA_Dilution: 1:10,000

Western_Blot_Dilution: 1:1000

Commentaires:

Anti-Phospho-Ser377 DGCR8 Antibody is tested for Western Blots and is specific for the ~120 kDa DGCR8 protein phosphorylated at Ser377. Immunolabeling is blocked by the phosphopeptide used as the antigen but not by the corresponding dephosphopeptide. Specific conditions for reactivity should be optimized by the end user.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer:

Buffer: 0.01 M HEPES, 0.15 M Sodium Chloride, pH 7.5

Stabilizer: 0.1 mg/mL Bovine Serum Albumin (BSA) - IgG and Protease free, 50 % (v/v) Glycerol

Preservative: None

Agent conservateur: Without preservative

Stock: -20 °C

Stockage commentaire: Store vial at -20° C prior to opening in undiluted aliquots. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. Dilute only prior to immediate use.

Date de péremption: 12 months

Détails sur DGCR8

Antigène: DGCR8 (DiGeorge Syndrome Critical Region Gene 8 (DGCR8))

Autre désignation: DGCR8

Sujet:

Synonyms: Microprocessor complex subunit DGCR8, DiGeorge syndrome critical region 8, C22orf12, DGCRK9

Background: The Drosha-DGCR8 microprocessor complex is required for microRNA (miRNA) biogenesis. DGCR8 (DiGeorge Syndrome Critical Region 8) recognizes the RNA substrate, whereas Drosha functions as the endonuclease. DGCR8, which contains two double-stranded RNA (dsRNA)-binding domains, interacts with the pri-miRNA and functions as the molecular anchor that measures the distance from the ds-RNA-ssRNA junction and directs Drosha cleavage 11bp away. The efficiency of Drosha cleavage increases in the presence of heme and promotes the formation of highly ordered DGCR8 structures upon binding to RNA. DGCR8 pS377 Antibody is ideal for researchers interested in neuroscience research.

Gene Name: DGCR8

ID gène: 1644

NCBI Accession: NP_001177255

UniProt: Q8WYQ5

Pathways: Regulatory RNA Pathways