HSPB8 anticorps

N° du produit ABIN6656214

N° du produit (Fournisseur): 100-401-f54

Cet anticorps Lapin Polyclonal détecte spécifiquement HSPB8 dans WB, IHC, IF, IP et FM. Il présente une réactivité envers Humain.

Aperçu rapide pour HSPB8 anticorps (ABIN6656214)

Antigène: HSPB8 (Heat Shock 22kDa Protein 8 (HSPB8))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp HSPB8 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP), Fluorescence Microscopy (FM)

Détail du produit anti-HSPB8 anticorps

N° du produit (Fournisseur): 100-401-f54

Fournisseur: Rockland

Fonction: HSP22 Antibody

Réactivité croisée (Details): A BLAST analysis was used to suggest cross-reactivity with Hsp22 from Human, Mouse, and Rat based on 100 % homology with the immunizing sequence.

Purification: Anti-Hsp22 Antibody was prepared from monospecific antiserum by delipidation and defibrination.

Stérilité: Sterile filtered

Immunogène: Hsp22 Antibody was produced from whole rabbit serum prepared by repeated immunizations raised against human Hsp22.

Isotype: IgG

Information d'application

Indications d'application:

Immunoprecipitation_Dilution: User Optimized

IF_Microscopy_Dilution: User Optimized

Western_Blot_Dilution: 1:1000

Commentaires:

Anti-Hsp22 Antibody has been tested in WB, IF, IHC, and IP. Expect a band approximately ~22kDa on specific lysates. Specific conditions for reactivity should be optimized by the end user.

Restrictions: For Research Use only

Stockage

Format: Liquid

Stock: 4 °C,-20 °C

Stockage commentaire: Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.

Date de péremption: 12 months

Détails sur HSPB8

Antigène: HSPB8 (Heat Shock 22kDa Protein 8 (HSPB8))

Autre désignation: Hsp22

Sujet:

Synonyms: Alpha crystallin C chain, CMT2L, CRYAC, DHMN2, H11, Heat shock 22 kDa protein 8, HMN2, HSB8, HspB8, Heat shock protein beta-8, E2IG1, HSP22, E2-induced gene 1 protein, Protein kinase H11

Background: Hsp22 (HSPB8) is a 196-amino acid protein that is a member of the small heat shock protein super-family and the human protein is most closely related to Hsp27. Similar to most other sHSPs, Hsp22 is predominately transcribed in skeletal muscle and heart, as well as the placenta. Hsp22 is a monomeric protein which interacts with HSPB1. It displays temperature-dependent chaperone activity. In a two hybrid screen, HspB8 interacted preferentially with a triple aspartate form of Hsp27 which mimics Hsp27 phosphorylated at Ser15, Ser78, and Ser82, as compared to wild-type Hsp27. HSPB8 has two binding domains (N and C Terminal) that are specific for different binding partners, and has the ability to bind itself and other sHSPs. The chaperone-like activity is of great importance to the function of Hsp22 in various processes including proliferation, apoptosis and macroautophagy. Mutations in the HSPB8 gene are associated with the inherited peripheral neurpathies, autosomal dominant distal hereditary motor neuropathy type IIA (dSMA) and axonal Charcot-Marie-Tooth disease type 2L (CMT2L).

Gene Name: HSPB8

ID gène: 26353

NCBI Accession: NP_055180

UniProt: Q9UJY1