Ataxin 1 anticorps (AA 746-761) (PE)

N° du produit ABIN6657681

N° du produit (Fournisseur): 200-308-w87

Cet anticorps Souris Monoclonal détecte spécifiquement Ataxin 1 dans WB, IHC et ELISA. Il présente une réactivité envers Souris.

Aperçu rapide pour Ataxin 1 anticorps (AA 746-761) (PE) (ABIN6657681)

Antigène: Ataxin 1 (ATXN1)

Reactivité: Souris

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Ataxin 1 est conjugé à/à la PE

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Clone: S65-37

Détail du produit anti-Ataxin 1 anticorps (PE)

Épitope: AA 746-761

N° du produit (Fournisseur): 200-308-w87

Fournisseur: Rockland

Fonction: Ataxin 1 Antibody Phycoerythrin

Réactivité croisée (Details): BLAST analysis suggests that it is 93 % identical to rat and 87 % identical to human.

Purification: Anti-Ataxin 1 Antibody was purified from concentrated tissue culture supernate by Protein G chromatography.

Stérilité: Sterile filtered

Immunogène: Anti-Ataxin 1 Antibody was produced by repeated immunization of mice with a synthetic peptide containing amino acids 746-761 of mouse ataxin-1.

Isotype: IgG1

Information d'application

Indications d'application:

ELISA_Dilution: 1:10,000

Western_Blot_Dilution: 1:1000

Commentaires:

Anti-Ataxin 1 R-PE Conjugated Antibody is suitable for Western Blots and Immunocytochemistry. Expect a band approximately ~85kDa on specific lysates or tissues. No cross reactivity against phosphor S751-Ataxin-1. Minimal cross reactivity against S751A mutant of Ataxin-1 by ELISA and immunofluorescence and negative by immunoblot. Specific conditions for reactivity should be optimized by the end user.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer:

Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2

Stabilizer: 50 % (v/v) Glycerol

Preservative: 0.1 % (w/v) Sodium Azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Store vial at 4° C prior to opening. Dilute only prior to immediate use. This product is stable at 4° C as an undiluted liquid. Use subdued lighting during handling and incubation of cells prior to analysis. Store reagent in the dark. DO NOT FREEZE.

Date de péremption: 12 months

Détails sur Ataxin 1

Antigène: Ataxin 1 (ATXN1)

Autre désignation: Ataxin 1

Sujet:

Synonyms: Ataxin-1, ATX1, Atxn1, D6S504E, OTTHUMP00000016065, SCA1, Spinocerebellar ataxia type 1 protein, Spinocerebellar ataxia type 1 protein homolog

Background: Ataxin-1 is a member of the ATXN1 protein family and contains a single AXH domain. It is a neurodegenerative disorder protein thought to have a role in the metabolism of RNA as it has been shown to localize to the RNA and transcription dependent inclusions within the nucleus. A mutation of Ataxin-1 is the cause of spinocerebellar ataxia type-1 (SCA1), a progressive, neurodegenerative disease that is autosomal dominant and primarily affects the Purjinke cells found in brain stem neuronal populations and the cerebellum. Expression of Ataxin-1 is almost ubiquitous, except in the brain where it is isolated to populations of neurons. Anti-Ataxin-1 is ideal for research in Neuroscience.

Gene Name: Ataxin-1

ID gène: 20238

UniProt: P54254

Pathways: Synaptic Membrane