NMDAR2A anticorps (pTyr1325)

N° du produit ABIN6658215

N° du produit (Fournisseur): 600-401-d90

Cet anticorps Lapin Polyclonal détecte spécifiquement NMDAR2A dans WB. Il présente une réactivité envers Rat.

Aperçu rapide pour NMDAR2A anticorps (pTyr1325) (ABIN6658215)

Antigène: NMDAR2A (GRIN2A) (Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2a (GRIN2A))

Reactivité: Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp NMDAR2A est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-NMDAR2A anticorps

Épitope: pTyr1325

N° du produit (Fournisseur): 600-401-d90

Fournisseur: Rockland

Fonction: NMDA R2A phospho Y1325 Antibody

Réactivité croisée (Details): Anti NMDA R2A pY1325 antibody is directed against NMDA R2A protein.

Purification: The antibody was affinity purified from monospecific antiserum by immunoaffinity purification.

Immunogène: Anti-NMDA R2A pY1325 Antibody was produced by repeated immunizations with a synthetic phospho-peptide corresponding to amino acid residues surrounding Tyr1325.

Isotype: IgG

Information d'application

Indications d'application:

Western_Blot_Dilution: 1:1000

Other: User Optimized

Commentaires:

Anti-NMDA R2A pY1325 Antibody is tested for use in Western Blotting. Specific conditions for reactivity should be optimized by the end user. Expect a band of approximately 180 kDa in size corresponding to NMDAR NR2A subunit protein phosphorylated at Tyr 1325 in the appropriate cell lysate or extract.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer:

Buffer: 0.01 M HEPES, 0.15 M Sodium Chloride, pH 7.5

Stabilizer: 0.1 mg/mL Bovine Serum Albumin (BSA) - IgG and Protease free, 50 % (v/v) Glycerol

Stock: 4 °C,-20 °C

Stockage commentaire: Store vial at -20° C prior to opening.  This product is stable at 4° C as an undiluted liquid.  For extended storage, aliquot contents and freeze at -20° C or below.  Avoid cycles of freezing and thawing. Dilute only prior to immediate use.

Date de péremption: 12 months

Détails sur NMDAR2A

Antigène: NMDAR2A (GRIN2A) (Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2a (GRIN2A))

Autre désignation: NMDA R2A

Sujet:

Synonyms: Glutamate [NMDA] receptor subunit epsilon-1, N-methyl D-aspartate receptor subtype 2A, NMDAR2A, NR2A, Grin2a

Background: NMDA R2A pY1325 Antibody detects NMDA R2A protein. The ion channels activated by glutamate that are sensitive to N-methyl-D-aspartate (NMDA) are designated NMDA receptors (NMDAR). The NMDAR plays an essential role in memory, neuronal development and it has also been implicated in several disorders of the central nervous system including Alzheimer's, epilepsy and ischemic neuronal cell death. The NMDA receptor is also one of the principal molecular targets for alcohol in the CNS. Channels with physiological characteristics are produced when the NR1 subunit is combined with one or more of the NMDAR2 (NR2 A-D) subunits. Recently, phosphorylation of Tyrosine 1325 of the NR2A subunit has been shown to be increased in human brain tissue sections from HIV-infected individuals with encephalitis. In addition, Tyr1325 phosphorylation has been linked with depression-related behavior. Anti-NMDA R2A pY1325 Antibody is ideal for investigators involved in Neuroscience, Signal Transduction, and Cell Signaling Research.

Gene Name: GRIN2A

ID gène: 24409

UniProt: Q00959

Pathways: Synaptic Membrane, Regulation of long-term Neuronal Synaptic Plasticity