GABRA1 anticorps (N-Term)

N° du produit ABIN6658221

N° du produit (Fournisseur): 600-401-d43

Cet anticorps Lapin Polyclonal détecte spécifiquement GABRA1 dans WB et IHC. Il présente une réactivité envers Rat.

Aperçu rapide pour GABRA1 anticorps (N-Term) (ABIN6658221)

Antigène: GABRA1 (gamma-aminobutyric Acid (GABA) A Receptor, alpha 1 (GABRA1))

Reactivité: Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp GABRA1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Détail du produit anti-GABRA1 anticorps

Épitope: N-Term

N° du produit (Fournisseur): 600-401-d43

Fournisseur: Rockland

Fonction: GABA(A) Receptor alpha 1 Antibody

Réactivité croisée (Details): Labeling is absent in α1-subunit knockout animals.

Purification: GABA(A) receptor alpha 1 antibodies are affinity purified from monospecific antiserum by immunoaffinity purification.

Immunogène: Anti-GABA(A) Receptor alpha 1 Antibody was produced in rabbit by repeated immunizations with synthetic peptide corresponding to amino acid residues from the N-terminal region of rat GABAA RA1 conjugated to KLH.

Isotype: IgG

Information d'application

Indications d'application: Optional[Neutralization_Dilution]: 1:1000

Commentaires:

Anti-GABA(A) Receptor alpha 1 (Rabbit) Antibody is tested for use in Western Blot and IHC. Specific conditions for reactivity should be optimized by the end user. Expect a band of approximately 51 kDa in size corresponding to the alpha 1 subunit of the GABA(A) receptor in rat brain.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer:

Buffer: 0.01 M HEPES, 0.15 M Sodium Chloride, pH 7.5

Stabilizer: 0.1 mg/mL Bovine Serum Albumin (BSA) - IgG and Protease free, 50 % (v/v) Glycerol

Stock: 4 °C,-20 °C

Stockage commentaire: Store vial at -20° C prior to opening.  This product is stable at 4° C as an undiluted liquid.  For extended storage, aliquot contents and freeze at -20° C or below.  Avoid cycles of freezing and thawing. Dilute only prior to immediate use.

Date de péremption: 12 months

Détails sur GABRA1

Antigène: GABRA1 (gamma-aminobutyric Acid (GABA) A Receptor, alpha 1 (GABRA1))

Autre désignation: GABA(A) Receptor alpha 1

Sujet:

Synonyms: Gamma-aminobutyric acid receptor subunit alpha-1, GABA(A) receptor subunit alpha-1

Background: Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system, causing a hyperpolarization of the membrane through the opening of a Cl- channel associated with the GABAA receptor (GABAA-R) subtype. GABAA-Rs are important therapeutic targets for a range of sedative, anxiolytic, and hypnotic agents and are implicated in several diseases including epilepsy, anxiety, depression, and substance abuse. The GABAA-R is a multimeric subunit complex. To date six αs, four βs and four γs, plus alternative splicing variants of some of these subunits, have been identified. Injection in oocytes or mammalian cell lines of cRNA coding for α- and β-subunits results in the expression of functional GABAA-Rs sensitive to GABA. However, coexpression of a γ-subunit is required for benzo-diazepine modulation. The various effects of the benzodiazepines in brain may also be mediated via different α-subunits of the receptor. GABA(A) receptor alpha 1 antibody is ideal for investigators involved in Neuroscience.

Gene Name: GABRA1

ID gène: 29705

UniProt: P62813