Synaptojanin 1 anticorps (C-Term)

N° du produit ABIN6658254

N° du produit (Fournisseur): 212-301-e35

Cet anticorps Souris Monoclonal détecte spécifiquement Synaptojanin 1 dans WB et IHC. Il présente une réactivité envers Rat.

Aperçu rapide pour Synaptojanin 1 anticorps (C-Term) (ABIN6658254)

Antigène: Synaptojanin 1 (SYNJ1)

Reactivité: Rat

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Synaptojanin 1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Clone: 5H1

Détail du produit anti-Synaptojanin 1 anticorps

Épitope: C-Term

N° du produit (Fournisseur): 212-301-e35

Fournisseur: Rockland

Fonction: Synaptojanin 1 Antibody

Réactivité croisée (Details): Anti-Synaptojanin 1 Monoclonal Antibody is directed against rat synaptojanin 1

Purification: .Synaptojanin 1 antibody was Protein G purified from cell culture supernatant.

Immunogène: Anti-Synaptojanin 1 Monoclonal Antibody was produced in mouse by repeated immunizations with recombinant protein from the C-terminal region of rat synaptojanin 1.

Isotype: IgG1

Information d'application

Indications d'application:

Immunohistochemistry_Dilution: 1:1000

Western_Blot_Dilution: 1:1000

Commentaires:

Anti-Synaptojanin 1 antibody is tested for use in Western Blotting and IHC. Expect a band of approximately 145 kDa in size corresponding to synaptojanin I proteins of rat brain extracts. Researchers should determine optimal titers for applications that are not stated below.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer:

Buffer: 0.01 M HEPES, 0.15 M Sodium Chloride, pH 7.5

Stabilizer: 0.1 mg/mL Bovine Serum Albumin (BSA) - IgG and Protease free, 50 % (v/v) Glycerol

Stock: 4 °C,-20 °C

Stockage commentaire: Store vial at -20° C prior to opening.  This product is stable at 4° C as an undiluted liquid.  For extended storage, aliquot contents and freeze at -20° C or below.  Avoid cycles of freezing and thawing. Dilute only prior to immediate use.

Date de péremption: 12 months

Détails sur Synaptojanin 1

Antigène: Synaptojanin 1 (SYNJ1)

Autre désignation: Synaptojanin 1

Sujet:

Synonyms: mouse anti-Synaptojanin 1 Antibody, Synaptic inositol-1,4,5-trisphosphate 5-phosphatase 1

Background: Synaptojanin 1 Monoclonal Antibody detects Synaptojanin 1, which is a phosphatidylinositol phosphatase involved in clathrin-mediated endocytosis of synaptic vesicles. Synaptojanin 1 has two alternatively spliced isoforms, one that is ~ 145 kDA and is exclusively expressed in neurons, and the other ~ 170 kDa which is expressed in non-neuronal, peripheral tissues. The gene which encodes Synaptojanin 1, SYNJ1, has been mapped to chromosome 21 thus making it a candidate for involvement in Down's syndrome (DS). It has recently been demonstrated that Ts65Dn mice (the most commonly used model of DS) have altered phosphatidylinositol-4,5-bisphosphate metabolism. This defect is rescued by restoring SYNJ1 to disomy in the Ts65Dn mice.

Gene Name: SYNJ1

ID gène: 85238

UniProt: Q62910

Pathways: Inositol Metabolic Process, Synaptic Vesicle Exocytosis