Factor VIII anticorps (AA 401-500)

N° du produit ABIN668601

Cet anticorps anti-Factor VIII est un anticorps Lapin Polyclonal détectant Factor VIII dans ELISA, ICC, IF (p), IF (cc), IHC (p) et IHC (fro). Adapté pour Humain, Souris, Rat et Lapin. Ce Primary Antibody a été cité dans 7+ publications.

Aperçu rapide pour Factor VIII anticorps (AA 401-500) (ABIN668601)

Antigène: Factor VIII (F8) (Coagulation Factor VIII (F8))

Reactivité: Humain, Souris, Rat, Lapin

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Factor VIII est non-conjugé

Application: ELISA, Immunocytochemistry (ICC), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Détail du produit anti-Factor VIII anticorps

Épitope: AA 401-500

Réactivité croisée: Humain, Souris, Lapin, Rat

Homologie: Dog

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from rat factor VIII

Isotype: IgG

Information d'application

Indications d'application: ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Date de péremption: 12 months

Références pour anticorps anti-Factor VIII (ABIN668601)

Hu, Wang, Leng, Hu, Shen, Song: "Heparanase mediates vascular endothelial growth factor gene transcription in high-glucose human retinal microvascular endothelial cells." dans: Molecular vision, Vol. 23, pp. 579-587, (2018) (PubMed).

Li, Zhang, Cao, Li, Ye, Shi, Wang, Sun, Wang, Jia, Wang: "Tanshinone IIA and Astragaloside IV promote the angiogenesis of mesenchymal stem cell-derived endothelial cell-like cells via upregulation of Cx37, Cx40 and Cx43." dans: Experimental and therapeutic medicine, Vol. 15, Issue 2, pp. 1847-1854, (2018) (PubMed).

Song, Li, Yu: "Effects of preserving different veins on flow-through flap survival: An experimental study." dans: Experimental and therapeutic medicine, Vol. 11, Issue 1, pp. 318-324, (2016) (PubMed).

Lei, Peng, Samuel, Zhang, Wu, Wang, Li, Liu: "A simple and biosafe method for isolation of human umbilical vein endothelial cells." dans: Analytical biochemistry, Vol. 508, pp. 15-8, (2016) (PubMed).

Yu, Zhang, Jiang, Wang, Zhang: "Astragalosides promote angiogenesis via vascular endothelial growth factor and basic fibroblast growth factor in a rat model of myocardial infarction." dans: Molecular medicine reports, Vol. 12, Issue 5, pp. 6718-26, (2015) (PubMed).

Ren, Fan, Mei, Wu, Liu, Pu, You, Liu: "Interferon-γ and celecoxib inhibit lung-tumor growth through modulating M2/M1 macrophage ratio in the tumor microenvironment." dans: Drug design, development and therapy, Vol. 8, pp. 1527-38, (2015) (PubMed).

Détails sur Factor VIII

Antigène: Factor VIII (F8) (Coagulation Factor VIII (F8))

Autre désignation: Factor 8

Sujet:

Synonyms: coagulation factor VIII, Ahf, Antihemophilic factor, Coagulation factor VIII, Coagulation factor VIII procoagulent component, Coagulation factor VIIIc, Dna segment on chromosome x unique 1253 expressed sequence, Dxs1253e, F8, F8 protein,F8c, FactorVIII, FVIII, Hema coagulation factor VIIIc procoagulent component, Hemophilia a, Hemophilia classic,

Background: This gene encodes coagulation factor VIII, which participates in the intrinsic pathway of blood coagulation, factor VIII is a cofactor for factor IXa which, in the presence of Ca+2 and phospholipids, converts factor X to the activated form Xa. This gene produces two alternatively spliced transcripts. Transcript variant 1 encodes a large glycoprotein, isoform a, which circulates in plasma and associates with von Willebrand factor in a noncovalent complex. This protein undergoes multiple cleavage events. Transcript variant 2 encodes a putative small protein, isoform b, which consists primarily of the phospholipid binding domain of factor VIIIc. This binding domain is essential for coagulant activity. Defects in this gene results in hemophilia A, a common recessive X-linked coagulation disorder. [provided by RefSeq, Jul 2008].

Poids moléculaire: 267kDa

ID gène: 302470

UniProt: Q7TN96