Thrombomodulin anticorps

N° du produit ABIN669636

Cet anticorps anti-Thrombomodulin est un anticorps Lapin Polyclonal détectant Thrombomodulin dans WB, IHC (p) et IF (p). Adapté pour Humain, Rat, Souris, Chien et Boeuf (Vache).

Aperçu rapide pour Thrombomodulin anticorps (ABIN669636)

Antigène: Thrombomodulin (THBD)

Reactivité: Humain, Rat, Souris, Chien, Boeuf (Vache)

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Thrombomodulin est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Détail du produit anti-Thrombomodulin anticorps

Réactivité croisée: Boeuf (Vache), Chien, Humain, Souris, Rat

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from mouse Thrombomodulin

Isotype: IgG

Information d'application

Indications d'application: WB(1:100-500)
Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C for 12 months.

Date de péremption: 12 months

Détails sur Thrombomodulin

Antigène: Thrombomodulin (THBD)

Autre désignation: Thrombomodulin

Sujet:

Synonyms: Thrombomodulin, CD 141, CD141, CD141 antigen, Fetomodulin, THBD, THRM, TM, AHUS 6, AHUS6, BDCA 3, BDCA3, THPH12, TRBM_HUMAN.

Background: Thrombomodulin, TM is cell surface glycoprotein, plays an important role in the protein C anticoagulant pathway. It located in a vein, artery and capillary endothelial cells on the surface of plasma membrane protein. It is generally believed: TM vascular endothelial injury is an important parameter is the thrombin receptor, known in a variety of normal human tissues, can also be expressed in many tumors, TM may be similar to the E-cadherin,and is a lectin Like activity of a new class of members of the cell adhesion molecules.CD141/Thrombomodulin is an exclusively endothelial cell surface glycoprotein that forms a 1:1 complex with thrombin. Binding of thrombin to this high-affinity receptor alters its specificity toward several substrates. The complex activates protein C approximately 1000 times faster than thrombin alone. Activated protein C degrades clotting factors V and VIII, thus, thrombomodulin converts thrombin into a physiologic anticoagulant. Thrombomodulin is also found in the circulatory and urinary systems, the physiologic significance of this is obscure.

Poids moléculaire: 61kDa

ID gène: 21824