Cardiac Troponin T2 anticorps (AA 88-298)

N° du produit ABIN6719304

Cet anticorps anti-Cardiac Troponin T2 est un anticorps Lapin Polyclonal détectant Cardiac Troponin T2 dans WB et ELISA. Adapté pour Humain, Souris et Rat.

Aperçu rapide pour Cardiac Troponin T2 anticorps (AA 88-298) (ABIN6719304)

Antigène: Cardiac Troponin T2 (cTnT) (Cardiac Troponin T (cTnT))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Cardiac Troponin T2 est non-conjugé

Application: Western Blotting (WB), ELISA

Détail du produit anti-Cardiac Troponin T2 anticorps

Épitope: AA 88-298

Fonction: Anti-Cardiac Troponin T/TNNT2 Antibody Picoband®

Réactivité croisée (Details): No cross-reactivity with other proteins.

Attributs du produit: Anti-Cardiac Troponin T/TNNT2 Antibody Picoband® (ABIN6719304). Tested in ELISA, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Purification: Immunogen affinity purified.

Immunogène: E. coli-derived human Cardiac Troponin T recombinant protein (Position: K88-K298).

Isotype: IgG

Information d'application

Indications d'application: Western blot, 0.1-0.5 μg/mL
ELISA, 0.1-0.5 μg/mL
1. Aviles, R. J., Askari, A. T., Lindahl, B., Wallentin, L., Jia, G., Ohman, E. M., Mahaffey, K. W., Newby, L. K., Califf, R. M., Simoons, M. L., Topol, E. J., Lauer, M. S. Troponin T levels in patients with acute coronary syndromes, with or without renal dysfunction. New Eng. J. Med. 346: 2047-2052, 2002. 2. Charlet-B, N., Logan, P., Singh, G., Cooper, T. A. Dynamic antagonism between ETR-3 and PTB regulates cell type-specific alternative splicing. Molec. Cell 9: 649-658, 2002. 3. Du, C.-K., Morimoto, S., Nishii, K., Minakami, R., Ohta, M., Tadano, N., Lu, Q.-W., Wang, Y.-Y., Zhan, D.-Y., Mochizuki, M., Kita, S., Miwa, Y., Takahashi-Yanaga, F., Iwamoto, T., Ohtsuki, I., Sasaguri, T. Knock-in mouse model of dilated cardiomyopathy caused by troponin mutation.Circ. Res. 101: 185-194, 2007.

Commentaires:

Tested Species: In-house tested species with positive results. Other applications have not been tested. Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na₂HPO₄, 0.05 mg NaN₃.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Détails sur Cardiac Troponin T2

Antigène: Cardiac Troponin T2 (cTnT) (Cardiac Troponin T (cTnT))

Autre désignation: TNNT2

Sujet:

Synonyms: Troponin T, cardiac muscle, TnTc, Cardiac muscle troponin T, cTnT, TNNT2

Tissue Specificity: Heart. The fetal heart shows a greater expression in the atrium than in the ventricle, while the adult heart shows a greater expression in the ventricle than in the atrium. Isoform 6 predominates in normal adult heart. Isoforms 1, 7 and 8 are expressed in fetal heart. Isoform 7 is also expressed in failing adult heart.

Background: Cardiac muscle troponin T (cTnT), is a protein which in humans is encoded by the TNNT2 gene. It is mapped to 1q32.1. The protein encoded by this gene is the tropomyosin-binding subunit of the troponin complex, which is located on the thin filament of striated muscles and regulates muscle contraction in response to alterations in intracellular calcium ion concentration. Mutations in this gene have been associated with familial hypertrophic cardiomyopathy as well as with dilated cardiomyopathy. Transcripts for this gene undergo alternative splicing that results in many tissue-specific isoforms, however, the full-length nature of some of these variants has not yet been determined.

Poids moléculaire: 43 kDa

ID gène: 7139

UniProt: P45379