IL-22 anticorps (AA 34-179) (DyLight 550)

N° du produit ABIN6719332

Cet anticorps Souris Monoclonal détecte spécifiquement IL-22 dans FACS. Il présente une réactivité envers Humain.

Aperçu rapide pour IL-22 anticorps (AA 34-179) (DyLight 550) (ABIN6719332)

Antigène: IL-22 (IL22) (Interleukin 22 (IL22))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp IL-22 est conjugé à/à la DyLight 550

Application: Flow Cytometry (FACS)

Clone: 7F2

Détail du produit anti-IL-22 anticorps (DyLight 550)

Épitope: AA 34-179

Fonction: Anti-Human IL22 DyLight® 550 conjugated Antibody(monoclonal, 7F2)

Réactivité croisée (Details): No cross-reactivity with other proteins.

Attributs du produit: Anti-Human IL22 DyLight® 550 conjugated Antibody (monoclonal, 7F2) (ABIN6719333)-Dyl550. Tested in Flow Cytometry applications. This antibody reacts with Human.

Purification: Immunogen affinity purified.

Immunogène: E. coli-derived human IL-22 recombinant protein (Position: A34-I179). Human IL-22 shares 81.4% amino acid (aa) sequence identity with mouse IL-22.

Isotype: IgG1

Information d'application

Indications d'application: Flow Cytometry (Fixed), 1-3 μg/1x10⁶ cells1. Dumoutier, L., Van Roost, E., Ameye, G., Michaux, L., Renauld, J.-C. IL-TIF/IL-22: genomic organization and mapping of the human and mouse genes. Genes Immunity 1: 488-494, 2000. 2. Moore KW, de Waal Malefyt R, Coffman RL, O'Garra A (2001). "Interleukin-10 and the interleukin-10 receptor". Annu. Rev. Immunol. 19: 683-765.

Commentaires:

Other applications have not been tested. Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Stockage

Format: Liquid

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: Lot specific

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Détails sur IL-22

Antigène: IL-22 (IL22) (Interleukin 22 (IL22))

Autre désignation: IL22

Sujet:

Synonyms: Interleukin-22, IL-22, Cytokine Zcyto18, IL-10-related T-cell-derived-inducible factor, IL-TIF, IL22, ILTIF, ZCYTO18, UNQ3099/PRO10096

Tissue Specificity: Expressed in submandibular and sublingual saliva but not in parotid saliva (at protein level). Expressed in various body fluids, such as the cerebrospinal fluid and plasma. Expressed in highest levels in the epididymis, vas deferens, brain, thymus, and ovary and the lowest in the submandibular gland.

Background: Interleukin-22 (IL-22), also known as ILTIF, is protein that in humans is encoded by the IL22 gene. IL-22 a member of a group of cytokines called the IL-10 family or IL-10 superfamily, a class of potent mediators of cellular inflammatory responses. Using FISH, the IL22 gene is mapped to chromosome 12q15, close to the IFNG and the herpesvirus saimiri-induced AK155 genes. IL-22 can contribute to immune disease through the stimulation of inflammatory responses, S100s and defensins. It also promotes hepatocyte survival in the liver and epithelial cells in the lung and gut similar to IL-10. In some contexts, the pro-inflammatory versus tissue-protective functions of IL-22 are regulated by the often co-expressed cytokine IL-17A.

Poids moléculaire: 39 kDa

ID gène: 50616