Neurexin 1 anticorps (AA 141-294) (DyLight 550)

N° du produit ABIN7354639

Cet anticorps anti-Neurexin 1 est un anticorps Lapin Polyclonal détectant Neurexin 1 dans FACS. Adapté pour Humain.

Aperçu rapide pour Neurexin 1 anticorps (AA 141-294) (DyLight 550) (ABIN7354639)

Antigène: Neurexin 1 (NRXN1)

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Neurexin 1 est conjugé à/à la DyLight 550

Application: Flow Cytometry (FACS)

Détail du produit anti-Neurexin 1 anticorps (DyLight 550)

Épitope: AA 141-294

Fonction: Anti-Human Neurexin 1 DyLight® 550 conjugated NRXN1 Antibody

Réactivité croisée (Details): No cross-reactivity with other proteins.

Attributs du produit: Anti-Human Neurexin 1 DyLight® 550 conjugated NRXN1 Antibody -Dyl550. Tested in Flow Cytometry applications. This antibody reacts with Human.

Purification: Immunogen affinity purified.

Immunogène: E. coli-derived human Neurexin 1 recombinant protein (Position: D141-E294).

Isotype: IgG

Information d'application

Indications d'application: Flow Cytometry (Fixed), 1-3 μg/1x10⁶ cells1. Comoletti, Davide, Flynn Robyn, Jennings Lori L, Chubykin Alexander, Matsumura Takehito, Hasegawa Hana, Südhof Thomas C, Taylor Palmer (Dec 2003). "Characterization of the interaction of a recombinant soluble neuroligin-1 with neurexin-1beta". J. Biol. Chem. United States. 278 (50): 50497-50505. 2. Nguyen T, Südhof TC (1997). "Binding properties of neuroligin 1 and neurexin 1beta reveal function as heterophilic cell adhesion molecules". J. Biol. Chem. 272 (41): 26032-26039.

Commentaires:

Other applications have not been tested. Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Détails sur Neurexin 1

Antigène: Neurexin 1 (NRXN1)

Autre désignation: NRXN1

Sujet:

Synonyms: Neurexin-1-beta, Neurexin I-beta, NRXN1

Background: Neurexin-1-alpha is a protein that in humans is encoded by the NRXN1 gene. This gene encodes a single-pass type I membrane protein that belongs to the neurexin family. Neurexins are cell-surface receptors that bind neuroligins to form Ca (2+)-dependent neurexin/neuroligin complexes at synapses in the central nervous system. This complex is required for efficient neurotransmission and is involved in the formation of synaptic contacts. Three members of this gene family have been studied in detail and are estimated to generate over 3,000 variants through the use of two alternative promoters (alpha and beta) and extensive alternative splicing in each family member. Recently, a third promoter (gamma) was identified for this gene in the 3' region. Mutations in this gene are associated with Pitt-Hopkins-like syndrome-2 and may contribute to susceptibility to schizophrenia.

Poids moléculaire: 39 kDa

ID gène: 9378

UniProt: P58400

Pathways: Synaptic Membrane, Skeletal Muscle Fiber Development