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DOK7 anticorps

DOK7 Reactivité: Humain, Souris, Rat WB, IF, IHC (p), ICC Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN6719428
  • Antigène Voir toutes DOK7 Anticorps
    DOK7 (Docking Protein 7 (DOK7))
    Reactivité
    Humain, Souris, Rat
    Hôte
    • 46
    • 4
    • 1
    • 1
    Lapin
    Clonalité
    • 48
    • 4
    Polyclonal
    Conjugué
    • 17
    • 5
    • 5
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp DOK7 est non-conjugé
    Application
    • 41
    • 22
    • 13
    • 13
    • 7
    • 7
    • 6
    • 3
    • 3
    • 3
    Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC)
    Fonction
    Rabbit IgG polyclonal antibody for DOK7 detection. Tested with WB, IHC-P, ICC/IF in Human,Mouse,Rat.
    Séquence
    STVEERVAQE ALETLQLEKR LSLLSHAGR
    Réactivité croisée (Details)
    No cross reactivity with other proteins.
    Attributs du produit
    Rabbit IgG polyclonal antibody for DOK7 detection. Tested with WB, IHC-P, ICC/IF in Human,Mouse,Rat.
    Purification
    Immunogen affinity purified.
    Immunogène
    A synthetic peptide corresponding to a sequence of human DOK7(STVEERVAQEALETLQLEKRLSLLSHAGR).
    Isotype
    IgG
    Top Product
    Discover our top product DOK7 Anticorps primaire
  • Indications d'application

    Application details: Western blot|0.1-0.5 μg/mL Immunohistochemistry(Paraffin-embedded Section)|0.5-1 μg/mL Immunocytochemistry/Immunofluorescence|2 μg/mL

    Commentaires

    Tested Species: In-house tested species with positive results. By Heat: Boiling the paraffin sections in 10mM citrate buffer, pH6.0, for 20mins is required for the staining of formalin/paraffin sections. Other applications have not been tested. Optimal dilutions should be determined by end users.

    Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
    Buffer
    Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C,-20 °C
    Stockage commentaire
    At -20°C for one year. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.
  • Antigène
    DOK7 (Docking Protein 7 (DOK7))
    Autre désignation
    DOK7 (DOK7 Produits)
    Synonymes
    anticorps si:dkey-180b4.3, anticorps si:ch211-164d19.2, anticorps C4orf25, anticorps CMS1B, anticorps A930013K19Rik, anticorps AW049091, anticorps Dok-7, anticorps EF-12, anticorps Oit5, anticorps RGD1566416, anticorps dok-7, anticorps docking protein 7, anticorps DOK7, anticorps dok7, anticorps Dok7
    Sujet

    Synonyms: Protein Dok-7, Downstream of tyrosine kinase 7, DOK7, C4orf25,

    Background: Dok-7 is a non-catalytic cytoplasmic adaptor protein that is expressed specifically in muscle and is essential for the formation of neuromuscular synapses. Further, Dok-7 contains pleckstrin homology (PH) and phosphotyrosine-binding (PTB) domains that are critical for Dok-7 function. It is mapped to 4p16.3. The protein encoded by this gene is essential for neuromuscular synaptogenesis. The protein functions in aneural activation of muscle-specific receptor kinase, which is required for postsynaptic differentiation, and in the subsequent clustering of the acetylcholine receptor in myotubes. This protein can also induce autophosphorylation of muscle-specific receptor kinase. Mutations in this gene are a cause of familial limb-girdle myasthenia autosomal recessive, which is also known as congenital myasthenic syndrome type 1B. Alternative splicing results in multiple transcript variants.

    ID gène
    285489
    Pathways
    Skeletal Muscle Fiber Development
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