SPAG5 anticorps (AA 1101-1193)

N° du produit ABIN672261

Cet anticorps anti-SPAG5 est un anticorps Lapin Polyclonal détectant SPAG5 dans ELISA, IF (cc), IF (p), IHC (fro) et IHC (p). Adapté pour Rat.

Aperçu rapide pour SPAG5 anticorps (AA 1101-1193) (ABIN672261)

Antigène: SPAG5 (Sperm Associated Antigen 5 (SPAG5))

Reactivité: Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SPAG5 est non-conjugé

Application: ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Détail du produit anti-SPAG5 anticorps

Épitope: AA 1101-1193

Réactivité croisée: Rat

Homologie: Human,Mouse,Dog,Cow,Pig,Horse

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human SPAG5/MAP126

Isotype: IgG

Information d'application

Indications d'application: ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Date de péremption: 12 months

Détails sur SPAG5

Antigène: SPAG5 (Sperm Associated Antigen 5 (SPAG5))

Autre désignation: SPAG5

Sujet:

Synonyms: MAP126, DEEPEST, hMAP126, Sperm-associated antigen 5, Astrin, Mitotic spindle-associated protein p126, SPAG5

Background: Essential component of the mitotic spindle required for normal chromosome segregation and progression into anaphase. Required for chromosome alignment, normal timing of sister chromatid segregation, and maintenance of spindle pole architecture. In complex with SKAP, promotes stable microtubule-kinetochore attachments. May contribute to the regulation of separase activity. May regulate AURKA localization to mitotic spindle, but not to centrosomes and CCNB1 localization to both mitotic spindle and centrosomes. In non-mitotic cells, upon stress induction, inhibits mammalian target of rapamycin complex 1 (mTORC1) association and recruits the mTORC1 component RPTOR to stress granules (SGs), thereby preventing mTORC1 hyperactivation-induced apoptosis. May enhance GSK3B-mediated phosphorylation of other substrates, such as MAPT/TAU.

ID gène: 10615

UniProt: Q96R06

Pathways: M Phase