PD-1 anticorps (Alexa Fluor 647)

N° du produit ABIN6727402

Cet anticorps Rat Monoclonal détecte spécifiquement PD-1 dans FACS. Il présente une réactivité envers Souris.

Aperçu rapide pour PD-1 anticorps (Alexa Fluor 647) (ABIN6727402)

Antigène: PD-1 (PDCD1) (Programmed Cell Death 1 (PDCD1))

Reactivité: Souris

Hôte: Rat

Clonalité: Monoclonal

Conjugué: Cet anticorp PD-1 est conjugé à/à la Alexa Fluor 647

Application: Flow Cytometry (FACS)

Clone: 29F-1A12

Détail du produit anti-PD-1 anticorps (Alexa Fluor 647)

Isotype: IgG2a kappa

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: PBS with 0.05 % Proclin300, 1 % BSA

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Store at 2~8°C and protected from prolonged exposure to light. Do not freeze.

Détails sur PD-1

Antigène: PD-1 (PDCD1) (Programmed Cell Death 1 (PDCD1))

Autre désignation: CD279/PD-1

Sujet:

Synonyms: PD-1, Programmed Death-1

Background: CD279, also known as programmed death-1 (PD-1), is a 50-55 kD glycoprotein belonging to the CD28 family of the Ig superfamily. PD-1 is expressed on activated splenic T and B cells and thymocytes. It is induced on activated myeloid cells as well. PD-1 is involved in lymphocyte clonal selection and peripheral tolerance through binding its ligands, B7-H1 (PD-L1) and B7-DC (PD-L2). It has been reported that PD-1 and PD-L1 interactions are critical to positive selection and play a role in shaping the T cell repertoire. PD-L1 negative costimulation is essential for prolonged survival of intratesticular islet allografts.

ID gène: 18566

UniProt: Q02242

Pathways: Cancer Immune Checkpoints