TNK2 anticorps (AA 301-420) (Cy7)
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- Antigène Voir toutes TNK2 Anticorps
- TNK2 (tyrosine Kinase, Non-Receptor, 2 (TNK2))
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Épitope
- AA 301-420
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Reactivité
- Humain, Souris, Rat
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp TNK2 est conjugé à/à la Cy7
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Application
- Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
- Réactivité croisée
- Humain, Souris, Rat
- Homologie
- Dog,Cow,Pig,Chicken
- Purification
- Purified by Protein A.
- Immunogène
- KLH conjugated synthetic peptide derived from human Ack1
- Isotype
- IgG
- Top Product
- Discover our top product TNK2 Anticorps primaire
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- Indications d'application
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IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 - Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 μg/μL
- Buffer
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
- Agent conservateur
- ProClin
- Précaution d'utilisation
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Stock
- -20 °C
- Stockage commentaire
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Date de péremption
- 12 months
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- Antigène
- TNK2 (tyrosine Kinase, Non-Receptor, 2 (TNK2))
- Autre désignation
- Ack1 (TNK2 Produits)
- Synonymes
- anticorps ACK, anticorps ACK-1, anticorps ACK1, anticorps p21cdc42Hs, anticorps AW552477, anticorps Ack, anticorps Cdgip, anticorps Pyk1, anticorps ack1, anticorps ackb, anticorps tnk2, anticorps tnk2b, anticorps wu:fj16g04, anticorps zgc:154019, anticorps tyrosine kinase non receptor 2, anticorps tyrosine kinase, non-receptor, 2, anticorps tyrosine kinase, non-receptor, 1, anticorps TNK2, anticorps Tnk2, anticorps tnk1
- Sujet
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Synonyms: ACK, ACK1, ACK-1, p21cdc42Hs, Activated CDC42 kinase 1, Tyrosine kinase non-receptor protein 2, TNK2
Background: Non-receptor tyrosine-protein and serine/threonine-protein kinase that is implicated in cell spreading and migration, cell survival, cell growth and proliferation. Transduces extracellular signals to cytosolic and nuclear effectors. Phosphorylates AKT1, AR, MCF2, WASL and WWOX. Implicated in trafficking and clathrin-mediated endocytosis through binding to epidermal growth factor receptor (EGFR) and clathrin. Binds to both poly- and mono-ubiquitin and regulates ligand-induced degradation of EGFR, thereby contributing to the accumulation of EGFR at the limiting membrane of early endosomes. Downstream effector of CDC42 which mediates CDC42-dependent cell migration via phosphorylation of BCAR1. May be involved both in adult synaptic function and plasticity and in brain development. Activates AKT1 by phosphorylating it on 'Tyr-176'. Phosphorylates AR on 'Tyr-267' and 'Tyr-363' thereby promoting its recruitment to androgen-responsive enhancers (AREs). Phosphorylates WWOX on 'Tyr-287'. Phosphorylates MCF2, thereby enhancing its activity as a guanine nucleotide exchange factor (GEF) toward Rho family proteins. Contributes to the control of AXL receptor levels. Confers metastatic properties on cancer cells and promotes tumor growth by negatively regulating tumor suppressor such as WWOX and positively regulating pro-survival factors such as AKT1 and AR.
- ID gène
- 10188
- UniProt
- Q07912
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