HTRA2 anticorps (AA 355-458) (Biotin)

N° du produit ABIN674216

L’anticorps Lapin Polyclonal anti-HTRA2 a été validé pour WB, ELISA, IHC (p) et IHC (fro). Il convient pour détecter HTRA2 dans des échantillons de Humain, Souris et Rat.

Aperçu rapide pour HTRA2 anticorps (AA 355-458) (Biotin) (ABIN674216)

Antigène: HTRA2 (HtrA Serine Peptidase 2 (HTRA2))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp HTRA2 est conjugé à/à la Biotin

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Détail du produit anti-HTRA2 anticorps (Biotin)

Épitope: AA 355-458

Réactivité croisée: Humain, Souris, Rat

Homologie: Dog,Cow,Rabbit

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human HtrA2

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C for 12 months.

Date de péremption: 12 months

Détails sur HTRA2

Antigène: HTRA2 (HtrA Serine Peptidase 2 (HTRA2))

Autre désignation: HtrA2/Omi

Sujet:

Synonyms: High temperature requirement protein a2, HTRA 2, HtrA like serine protease, HtrA serine peptidase 2, Omi stress regulated endoprotease, PARK 13, PARK13, Protease serine 25, PRSS 25, PRSS25, Serine protease 25, Serine protease HTRA2 mitochondrial, HtrA2, HTRA2_HUMAN, mitochondrial, Omi stress-regulated endoprotease, Serine protease HTRA2, Serine proteinase OMI, Serine protease htra2 mitochondrial precursor, Serine protease omi.

Background: Serine protease that shows proteolytic activity against a non-specific substrate beta-casein. Promotes or induces cell death either by direct binding to and inhibition of BIRC proteins(also called inhibitor of apoptosis proteins, IAPs), leading to an increase in caspase activity, or by a BIRC inhibition-independent, caspase-independent and serine protease activity-dependent mechanism. Isoform 2 seems to be proteolytically inactive. [CATALYTIC ACTIVITY] Cleavage of non-polar aliphatic amino-acids at the P1 position, with a preference for Val, Ile and Met. At the P2 and P3 positions, Arg is selected most strongly with a secondary preference for other hydrophilic residues. [SUBUNIT] Homotrimer. Interacts with MXI2. The mature protein, but not the precursor, binds to BIRC2, BIRC3 and XIAP.

ID gène: 27429

UniProt: O43464

Pathways: Positive Regulation of Endopeptidase Activity