PAR1 anticorps (AA 267-316)

N° du produit ABIN6746560

Cet anticorps Lapin Polyclonal détecte spécifiquement PAR1 dans WB. Il présente une réactivité envers Humain, Rat, Souris, Porc et Lapin et a été mentionné dans 3+ publications.

Aperçu rapide pour PAR1 anticorps (AA 267-316) (ABIN6746560)

Antigène: PAR1 (F2R) (Coagulation Factor II (thrombin) Receptor (F2R))

Reactivité: Humain, Rat, Souris, Porc, Lapin

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PAR1 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-PAR1 anticorps

Épitope: AA 267-316

Specificité: Human F2R / Thrombin Receptor

Homologie: Percent identity by BLAST analysis: Mouse, Rat (100%) Dog (92%) Pig (85%) Rabbit (84%).

Purification: Immunoaffinity purified

Immunogène: Synthetic peptide located between aa267-316 of human F2R (P25116, NP_001983). Percent identity by BLAST analysis: Human, Chimpanzee, Gorilla, Mouse, Rat (100%), Gibbon, Baboon, Monkey, Galago, Marmoset, Hamster, Dog, Horse (92%), Pig (85%), Rabbit (84%).

Type of Immunogen: Synthetic peptide

Information d'application

Indications d'application: Approved: WB (0.2 - 1 μg/mL)

Usage: Western Blot: Suggested dilution at 1 μg/mL in 5 % skim milk / PBS buffer, and HRP conjugated anti-Rabbit IgG should be diluted in 1: 50,000 - 100,000 as secondary antibody.

Commentaires:

Target Species of Antibody: Human

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Distilled water

Concentration: Lot specific

Buffer: Lyophilized from PBS with 2 % sucrose

Conseil sur la manipulation: Avoid repeat freeze-thaw cycles.

Stock: 4 °C,-20 °C

Stockage commentaire: Long term: -20°C, the use of 50% glycerol is recommended if storing aliquots in -20°C for long term use (up to 1 year)
Short term (less than 1 week): 4°C. Avoid freeze-thaw cycles.

Références pour anticorps anti-PAR1 (ABIN6746560)

Gradin, Larsson, Marklund, Gullberg: "Regulation of microtubule dynamics by extracellular signals: cAMP-dependent protein kinase switches off the activity of oncoprotein 18 in intact cells." dans: The Journal of cell biology, Vol. 140, Issue 1, pp. 131-41, (1998) (PubMed).

Horwitz, Shen, He, Dittmar, Neef, Chen, Schubart: "The microtubule-destabilizing activity of metablastin (p19) is controlled by phosphorylation." dans: The Journal of biological chemistry, Vol. 272, Issue 13, pp. 8129-32, (1997) (PubMed).

Larsson, Marklund, Gradin, Brattsand, Gullberg: "Control of microtubule dynamics by oncoprotein 18: dissection of the regulatory role of multisite phosphorylation during mitosis." dans: Molecular and cellular biology, Vol. 17, Issue 9, pp. 5530-9, (1997) (PubMed).

Détails sur PAR1

Antigène: PAR1 (F2R) (Coagulation Factor II (thrombin) Receptor (F2R))

Autre désignation: F2R / Thrombin Receptor / PAR1

Sujet: Name/Gene ID: F2R
Subfamily: Proteinase-activated
Family: GPCR

Synonyms: F2R, CF2R, Coagulation factor II receptor, PAR1, PAR-1, Thrombin receptor, TR, HTR, Protease-activated receptor 1

ID gène: 2149

NCBI Accession: NP_001983

UniProt: P25116

Pathways: Nuclear Receptor Transcription Pathway, Skeletal Muscle Fiber Development, Positive Regulation of Endopeptidase Activity, Protein targeting to Nucleus