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AU5 Epitope Tag anticorps

TDFYLK Reactivité: Tag ELISA, ICC Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN677708
  • Antigène Tous les produits AU5 Epitope Tag (TDFYLK)
    AU5 Epitope Tag (TDFYLK)
    Reactivité
    Tag
    Hôte
    • 4
    • 3
    Lapin
    Clonalité
    • 7
    Polyclonal
    Conjugué
    • 5
    • 1
    • 1
    Cet anticorp AU5 Epitope Tag est non-conjugé
    Application
    • 7
    • 5
    • 5
    • 3
    • 2
    ELISA, Immunocytochemistry (ICC)
    Séquence
    TDFYLK
     Réactivité croisée
    Tag
    Réactivité croisée (Details)
    fusion protein,tagged T7 tag
    Attributs du produit
    Antibody is specific for: fusion protein,tagged T7 tag
    Purification
    Purified by Protein A.
    Immunogène
    KLH conjugated to AU5 tag
    Isotype
    IgG
  • Indications d'application
    ELISA 1:500-1000
    ICC 1:100-500
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
    Agent conservateur
    ProClin
    Précaution d'utilisation
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Stock
    4 °C,-20 °C
    Stockage commentaire
    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    Date de péremption
    12 months
  • Antigène
    AU5 Epitope Tag (TDFYLK)
    Autre désignation
    AU5 tag (TDFYLK Produits)
    Classe de substances
    Tag
    Sujet

    Synonyms: AU5 epitope tag, TDFYLK epitope tag, TDFYLK tag.

    Background: Core protein packages viral RNA to form a viral nucleocapsid, and promotes virion budding. Modulates viral translation initiation by interacting with HCV IRES and 40S ribosomal subunit. Also regulates many host cellular functions such as signaling pathways and apoptosis. Prevents the establishment of cellular antiviral state by blocking the interferon-alpha/beta (IFN-alpha/beta) and IFN-gamma signaling pathways and by inducing human STAT1 degradation. Plays an important role in virus-mediated cell transformation leading to hepatocellular carcinomas. Interacts with, and activates STAT3 leading to cellular transformation. May repress the promoter of p53, and sequester CREB3 and SP110 isoform3/Sp110b in the cytoplasm. Also represses cell cycle negative regulating factor CDKN1A, thereby interrupting an important check point of normal cell cycle regulation. Targets transcription factors involved in the regulation of inflammatory responses and in the immune response: suppresses NK-kappaB activation, and activates AP-1. Mediates apoptotic pathways throught association with TNF-type receptors TNFRSF1A and LTBR, although its effect on death receptors-induced apoptosis remains controvertial. Enhances TRAIL mediated apoptosis, suggesting that it might play a role in mediated apoptosis, suggesting that it might play a role in immune-mediated liver cell injury. Secreted core protein is able to bind C1QR1 at the T-cell surface, resulting in down-regulation of T-lymphocytes proliferation. May transactivate human MYC, Rous sarcoma virus LTR, and SV40 promoters. May suppress the human FOS and HIV-1 LTR activity. May alter lipid metabolism by interacting with hepatocellular proteins involved in lipid accumulation and storage.

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