PKD1 anticorps (AA 131-230)

N° du produit ABIN678083

4+ publications sont disponibles pour ce produit. L’anticorps anti-PKD1 Polyclonal produit chez le Lapin a été validé pour ELISA, WB, IHC (p), FACS, IF (cc), IF (p), ICC et IHC (fro). Il convient pour la détection de PKD1 dans des échantillons provenant de Humain et Souris. }

Aperçu rapide pour PKD1 anticorps (AA 131-230) (ABIN678083)

Antigène: PKD1 (Polycystic Kidney Disease 1 (Autosomal Dominant) (PKD1))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PKD1 est non-conjugé

Application: ELISA, Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunocytochemistry (ICC), Immunohistochemistry (Frozen Sections) (IHC (fro))

Détail du produit anti-PKD1 anticorps

Épitope: AA 131-230

Réactivité croisée: Humain, Souris

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human Polycystin 1

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
ELISA 1:500-1000
FCM 1:20-100
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Date de péremption: 12 months

Références pour anticorps anti-PKD1 (ABIN678083)

Ren, Xia, Yang, Zhu, Zhang, Chen, Zhao, Sun, Zhao: "Down-regulation of polycystin in lymphatic malformations: possible role in the proliferation of lymphatic endothelial cells." dans: Human pathology, Vol. 65, pp. 231-238, (2017) (PubMed).

Kito, Saigo, Takeuchi: "Novel Transgenic Mouse Model of Polycystic Kidney Disease." dans: The American journal of pathology, Vol. 187, Issue 9, pp. 1916-1922, (2017) (PubMed).

Ohata, Herranz-Pérez, Nakatani, Boletta, García-Verdugo, Álvarez-Buylla: "Mechanosensory Genes Pkd1 and Pkd2 Contribute to the Planar Polarization of Brain Ventricular Epithelium." dans: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 35, Issue 31, pp. 11153-68, (2015) (PubMed).

Chiou, Sang, Cheng, Ho, Wang, Pan: "Peracetylated (-)-epigallocatechin-3-gallate (AcEGCG) potently prevents skin carcinogenesis by suppressing the PKD1-dependent signaling pathway in CD34+ skin stem cells and skin tumors." dans: Carcinogenesis, Vol. 34, Issue 6, pp. 1315-22, (2013) (PubMed).

Détails sur PKD1

Antigène: PKD1 (Polycystic Kidney Disease 1 (Autosomal Dominant) (PKD1))

Autre désignation: Polycystin 1

Sujet:

Synonyms: PBP, Pc-1, TRPP1, Polycystin-1, Autosomal dominant polycystic kidney disease 1 protein, PKD1

Background: Involved in renal tubulogenesis. Involved in fluid-flow mechanosensation by the primary cilium in renal epithelium. Acts as a regulator of cilium length, together with PKD2. The dynamic control of cilium length is essential in the regulation of mechanotransductive signaling. The cilium length response creates a negative feedback loop whereby fluid shear-mediated deflection of the primary cilium, which decreases intracellular cAMP, leads to cilium shortening and thus decreases flow-induced signaling (By similarity). May be an ion-channel regulator. Involved in adhesive protein-protein and protein-carbohydrate interactions.

ID gène: 5310

UniProt: P98161

Pathways: Myometrial Relaxation and Contraction, Maintenance of Protein Location