PKD1 anticorps (AA 131-230) (Biotin)

N° du produit ABIN678085

Cet anticorps Lapin Polyclonal détecte spécifiquement PKD1 dans ELISA, WB, IHC (p) et IHC (fro). Il présente une réactivité envers Humain et Souris.

Aperçu rapide pour PKD1 anticorps (AA 131-230) (Biotin) (ABIN678085)

Antigène: PKD1 (Polycystic Kidney Disease 1 (Autosomal Dominant) (PKD1))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PKD1 est conjugé à/à la Biotin

Application: ELISA, Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Détail du produit anti-PKD1 anticorps (Biotin)

Épitope: AA 131-230

Réactivité croisée: Humain, Souris

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human Polycystin 1

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C for 12 months.

Date de péremption: 12 months

Détails sur PKD1

Antigène: PKD1 (Polycystic Kidney Disease 1 (Autosomal Dominant) (PKD1))

Autre désignation: Polycystin 1

Sujet:

Synonyms: PBP, Pc-1, TRPP1, Polycystin-1, Autosomal dominant polycystic kidney disease 1 protein, PKD1

Background: Involved in renal tubulogenesis. Involved in fluid-flow mechanosensation by the primary cilium in renal epithelium. Acts as a regulator of cilium length, together with PKD2. The dynamic control of cilium length is essential in the regulation of mechanotransductive signaling. The cilium length response creates a negative feedback loop whereby fluid shear-mediated deflection of the primary cilium, which decreases intracellular cAMP, leads to cilium shortening and thus decreases flow-induced signaling (By similarity). May be an ion-channel regulator. Involved in adhesive protein-protein and protein-carbohydrate interactions.

ID gène: 5310

UniProt: P98161

Pathways: Myometrial Relaxation and Contraction, Maintenance of Protein Location