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beta Catenin anticorps (pSer45, pThr41) (Biotin)

CATNB Reactivité: Humain, Rat ELISA, IHC (p), IHC (fro) Hôte: Lapin Polyclonal Biotin

N° du produit ABIN683955

Fiche de données

Antigène Voir toutes beta Catenin (CATNB) Anticorps

beta Catenin (CATNB) (Catenin, beta (CATNB))
Épitope
42

26

21

21

20

17

17

17

17

16

16

15

9

8

7

7

3

3

2

2

2

2

2

2

2

2

2

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
pSer45, pThr41
Reactivité
331

247

226

29

23

22

18

18

5

5

5

5

1

1

1

1

1

1

1

1
Humain, Rat
Hôte
270

60

4

2

1
Lapin
Anticorps secondaires appropriés
Clonalité
265

72
Polyclonal
Conjugué
124

21

16

15

15

15

15

15

11

10

9

9

9

9

9

8

4

4

4

4

4

4

1

1

1
Cet anticorp beta Catenin est conjugé à/à la Biotin
Application
208

159

120

118

73

63

62

48

35

30

22

9

7

4

1

1

1

1
ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Specificité

This phophorylation site is homologous to that of Thr41 + Ser45 in Mouse and Rat.

Réactivité croisée

Humain, Rat

Homologie

Mouse,Cow,Pig,Horse,Chicken,Rabbit

Purification

Purified by Protein A.

Immunogène

KLH conjugated synthetic phosphopeptide derived from human Beta-Catenin around the phosphorylation site of Thr41/Ser45

Isotype

IgG

Top Product

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anti-Catenin, beta (CATNB) (C-Term) antibody
CATNB Reactivité: Humain, Souris, Rat, Boeuf (Vache), Poisson zèbre (Danio rerio), Xenopus laevis WB, ELISA Hôte: Lapin Polyclonal unconjugated

anti-Catenin, beta (CATNB) (pSer33), (pSer37) antibody
CATNB Reactivité: Humain, Souris, Rat WB, FACS, ELISA, IF (cc), IF (p), IHC (p), ICC, IHC (fro) Hôte: Lapin Polyclonal unconjugated

anti-Catenin, beta (CATNB) (AA 661-781) antibody
CATNB Reactivité: Humain, Souris, Rat, Porc, Poisson zèbre (Danio rerio) WB, FACS, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) Hôte: Lapin Polyclonal unconjugated

anti-Catenin, beta (CATNB) (C-Term) antibody
CATNB Reactivité: Humain, Souris, Rat, Poulet, Boeuf (Vache), Chien, Porc, Lapin, Mouton, Singe, Hamster, Avian, Cat, Âne, Chévre, Cobaye, Cheval WB, IF Hôte: Chèvre Polyclonal unconjugated

anti-Catenin, beta (CATNB) (pSer33), (pSer37), (pThr41) antibody
CATNB Reactivité: Humain, Souris, Rat WB, IHC Hôte: Lapin Polyclonal unconjugated

anti-Catenin, beta (CATNB) antibody
CATNB Reactivité: Humain, Souris, Rat WB, IHC, IF Hôte: Lapin Polyclonal unconjugated

anti-Catenin, beta (CATNB) (AA 439-675) antibody
CATNB Reactivité: Humain WB, IHC, IP, ICC Hôte: Lapin Polyclonal unconjugated

anti-Catenin, beta (CATNB) (AA 439-675) antibody
CATNB Reactivité: Humain WB, IHC, IP, ICC Hôte: Souris Monoclonal C901 unconjugated

anti-Catenin, beta (CATNB) antibody
CATNB Reactivité: Humain, Souris, Hamster WB, FACS, IP, ICC Hôte: Souris Monoclonal EM-22 unconjugated

anti-Catenin, beta (CATNB) antibody
CATNB Reactivité: Humain, Souris, Rat WB, IHC Hôte: Souris Monoclonal 4A3H3 unconjugated

Indications d'application

IHC-P 1:200-400
IHC-F 1:100-500

Restrictions

For Research Use only
Format

Liquid

Concentration

1 μg/μL

Buffer

Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur

ProClin

Précaution d'utilisation

This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock

-20 °C

Stockage commentaire

Store at -20°C for 12 months.

Date de péremption

12 months
Antigène

beta Catenin (CATNB) (Catenin, beta (CATNB))

Autre désignation

Beta Catenin + (CATNB Produits)

Synonymes

anticorps Bfc, anticorps Catnb, anticorps Mesc, anticorps CTNNB, anticorps MRD19, anticorps armadillo, anticorps ctnnb, anticorps id:ibd2058, anticorps wu:fb73e10, anticorps wu:fi81c06, anticorps wu:fk25h01, anticorps beta-catenin, anticorps ctnnb1, anticorps CHBCAT, anticorps catenin (cadherin associated protein), beta 1, anticorps catenin beta 1, anticorps catenin (cadherin-associated protein), beta 1, anticorps catenin beta 1 L homeolog, anticorps Ctnnb1, anticorps CTNNB1, anticorps ctnnb1, anticorps ctnnb1.L

Sujet

Synonyms: CTNNB, MRD19, armadillo, Catenin beta-1, Beta-catenin, CTNNB1, OK/SW-cl.35, PRO2286
Background: Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes. Involved in the regulation of cell adhesion. Acts as a negative regulator of centrosome cohesion. Involved in the CDK2/PTPN6/CTNNB1/CEACAM1 pathway of insulin internalization. Blocks anoikis of malignant kidney and intestinal epithelial cells and promotes their anchorage-independent growth by down-regulating DAPK2. Disrupts PML function and PML-NB formation by inhibiting RANBP2-mediated sumoylation of PML.

ID gène

1499

UniProt

P35222

Pathways

Peptide Hormone Metabolism