ACP5 anticorps
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- Antigène Voir toutes ACP5 Anticorps
- ACP5 (Acid Phosphatase 5, Tartrate Resistant (ACP5))
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Reactivité
- Humain
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Hôte
- Souris
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Clonalité
- Monoclonal
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Conjugué
- Cet anticorp ACP5 est non-conjugé
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Application
- Immunohistochemistry (Formalin-fixed Sections) (IHC (f))
- Specificité
- It recognizes a protein of 35kDa, which is identified as tartrate-resistant acid phosphatase (TRAcP). It exists as two isoforms (5a and 5b). This MAb reacts with both the isoforms. Serum TRAcP 5a is secreted by macrophages and dendritic cells and increased in many patients of rheumatoid arthritis.Serum TRAcP 5b is produced from osteoclasts and elevated during bone resorption. TRAcP is an iron containing glycoprotein, which catalyzes the conversion of orthophosphoric monoester to alcohol and orthophosphate. It is the most basic of the acid phosphatases and is the only form not inhibited by L(+)-tartrate. TRAcP is synthesized as a latent proenzyme and is activated by proteolytic cleavage and reduction. Normally, TRAcP is highly expressed by osteoclasts, activated macrophages, neurons and endometrium during pregnancy. Expression of TRAcP is increased in certain pathological conditions such as Leukemic Reticuloendotheliosis (Hairy Cell Leukemia), Gaucher's Disease, HIV-induced Encephalopathy, Osteoclastoma and in osteoporosis and metabolic bone diseases. Anti-TRAcP antibody labels the cells of Hairy Cell Leukemia (HCL) with a high degree of sensitivity and specificity. Other cells stained with this antibody are tissue macrophages and osteoclasts.
- Réactivité croisée (Details)
- Human. Mouse. Rat.
- Purification
- 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.
- Immunogène
- Recombinant full-length human ACP5 protein
- Clone
- ACP5-1070
- Isotype
- IgG2b kappa
- Top Product
- Discover our top product ACP5 Anticorps primaire
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- Indications d'application
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Known_Application: Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes), Optimal dilution for a specific application should be determined.
Positive_Control: HepG2, 293T, K562 or RPMI-8226 cells. Spleen from Hairy Cell Leukemia (HCL) patient.
- Restrictions
- For Research Use only
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- Concentration
- 1.0 mg/mL
- Buffer
- Prepared in 10 mM PBS, WITHOUT BSA and Azide.
- Agent conservateur
- Azide free
- Stock
- -20 °C,-80 °C
- Stockage commentaire
- Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.
- Date de péremption
- 24 months
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- Antigène
- ACP5 (Acid Phosphatase 5, Tartrate Resistant (ACP5))
- Autre désignation
- ACP5 (ACP5 Produits)
- Synonymes
- anticorps SPENCDI, anticorps TRAP, anticorps acp5, anticorps sb:cb576, anticorps zgc:63825, anticorps wu:fb19f01, anticorps wu:fb30b03, anticorps wu:fi14e01, anticorps wu:fj66f03, anticorps MGC78938, anticorps MGC89674, anticorps TR-AP, anticorps zgc:92339, anticorps TRACP, anticorps TTRRAP, anticorps Trap, anticorps UF, anticorps acid phosphatase 5, tartrate resistant, anticorps acid phosphatase 5a, tartrate resistant, anticorps acid phosphatase 5, tartrate resistant S homeolog, anticorps tartrate resistant acid phosphatase, anticorps Tartrate-resistant acid phosphatase type 5, anticorps tartrate-resistant acid phosphatase type 5, anticorps acid phosphatase 5b, tartrate resistant, anticorps ACP5, anticorps acp5a, anticorps acp5.S, anticorps acp5, anticorps NAEGRDRAFT_81291, anticorps ppa5, anticorps LOC100282899, anticorps acp5b, anticorps Acp5
- Sujet
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Acid phosphatase 5, tartrate resistant, ACP5, serum band 5 tartrate-resistant acid phosphatase, SPENCDI, Tartrate-resistant acid ATPase, Tartrate-resistant acid phosphatase type 5, TR-AP, TRACP5, TRAcP, TRAP, TrATPase, Type 5 acid phosphatase,TRAcP (Tartrate-Resistant Acid Phosphatase) (Hairy Cell Leukemia Marker)
Cellular localisation: Cytoplasmic (Lysosomes) - Poids moléculaire
- 35kDa
- ID gène
- 54, 1211
- UniProt
- P13686
- Pathways
- Transition Metal Ion Homeostasis
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