CD46 anticorps

N° du produit ABIN6936735

L’anticorps anti-CD46 Monoclonal Souris est utilisé pour la détection de CD46 dans des échantillons de Humain et Babouin. Il a été validé pour FACS et IF.

Aperçu rapide pour CD46 anticorps (ABIN6936735)

Antigène: CD46

Reactivité: Humain, Babouin

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp CD46 est non-conjugé

Application: Flow Cytometry (FACS), Immunofluorescence (IF)

Clone: 169-1-E4-3

Détail du produit anti-CD46 anticorps

Fonction: CD46 (Membrane Cofactor Protein) Antibody

Specificité: Recognizes a protein of 52 kDa-58 kDa, identified as CD46 (also known as membrane cofactor protein, MCP). Its epitope is located on the four immunogenic short consensus repeat (SCR) domains at N-terminus of the protein. CD46 exists as many isoforms in a variety of tissues. It is strongly expressed on salivary gland ducts and kidney ducts, moderately on lymphocytes and endothelium, and weakly on interstitial tissues and muscle cells, but not on erythrocytes. CD46 functions as a C3b/C4b-binding glycoprotein that inhibits complement activation on host cells. It also serves as a measles virus receptor, an adherence factor for group Streptococcus pyogenes, and a cellular pilus receptor for pathogenic Neisseria.

Aucune reactivité croisée: Cheval

Réactivité croisée (Details): Human. Baboon. Does not react with Horse.

Purification: 200ug/ml of Ab Purified from Bioreactor Concentrate.

Immunogène: Stimulated human leukocytes

Isotype: IgG2a, kappa

Information d'application

Indications d'application:

Known_Application: Flow Cytometry (1-2 μg/million cells), Immunofluorescence (1-2 μg/mL), Optimal dilution for a specific application should be determined.

Positive_Control: K562, U937, HL60, HeLa and Jurkat cells and human lymphocytes. Lymph node and tonsil.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: Prepared in 10  mM PBS

Agent conservateur: Azide free

Stock: -20 °C,-80 °C

Stockage commentaire: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Date de péremption: 24 months

Détails sur CD46

Antigène: CD46

Autre désignation: CD46

Sujet:

AHUS2, Complement membrane cofactor protein, MCP, Measles virus receptor, Membrane cofactor protein, MIC10, TLX, Trophoblast leucocyte common antigen, Trophoblast lymphocyte cross reactive antigen

HeLa and Jurkat cells and human lymphocytes. Lymph node and tonsil., HL60, K562, U937

Poids moléculaire: 52-58kDa

ID gène: 4179, 510402

UniProt: P15529

Pathways: Regulation of Actin Filament Polymerization