CD46 anticorps

N° du produit ABIN6936737

Cet anticorps Souris Monoclonal détecte spécifiquement CD46 dans FACS, IF et Func. Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour CD46 anticorps (ABIN6936737)

Antigène: CD46

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp CD46 est non-conjugé

Application: Flow Cytometry (FACS), Immunofluorescence (IF), Functional Studies (Func)

Clone: 122-2

Détail du produit anti-CD46 anticorps

Fonction: CD46 (Membrane Cofactor Protein) Antibody

Specificité: CD46 acts as a cofactor for complement factor I, a serine protease, which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. It may be involved in the fusion of the spermatozoa with the oocyte during fertilization. CD46 acts as a co-stimulatory factor for T-cells, which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity. A number of viral and bacterial pathogens seem to exploit this property and directly induce an immunosuppressive phenotype in T-cells by binding to CD46.

Réactivité croisée (Details): Human.

Purification: 200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G.

Immunogène: Recombinant human CD46 protein

Isotype: IgG1, kappa

Information d'application

Indications d'application:

Known_Application: Functional Studies (Order Ab without Azide),Flow Cytometry (1-2 μg/million cells), Immunofluorescence (1-2 μg/mL), Optimal dilution for a specific application should be determined.

Positive_Control: HeLa, K-562 or MOLT-4 cells. Kidney.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: Prepared in 10  mM PBS

Agent conservateur: Azide free

Stock: -20 °C,-80 °C

Stockage commentaire: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Date de péremption: 24 months

Détails sur CD46

Antigène: CD46

Autre désignation: CD46

Sujet:

AHUS2, CD46 antigen complement regulatory protein, Complement membrane cofactor protein, MCP, Measles virus receptor, Membrane cofactor protein, MIC10, TLX, Trophoblast leucocyte common antigen

HeLa, K-562 or MOLT-4 cells. Kidney.

Poids moléculaire: 56-66kDa

ID gène: 4179, 510402

UniProt: P15529

Pathways: Regulation of Actin Filament Polymerization