Cathepsin K anticorps (AA 163-274)

N° du produit ABIN6937059

L’anticorps Souris Monoclonal anti-Cathepsin K a été validé pour IHC et IHC (f). Il convient pour détecter Cathepsin K dans des échantillons de Humain.

Aperçu rapide pour Cathepsin K anticorps (AA 163-274) (ABIN6937059)

Antigène: Cathepsin K (CTSK)

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Cathepsin K est non-conjugé

Application: Immunohistochemistry (IHC), Immunohistochemistry (Formalin-fixed Sections) (IHC (f))

Clone: CTSK-2791

Détail du produit anti-Cathepsin K anticorps

Épitope: AA 163-274

Specificité: The protein encoded by this gene is a lysosomal cysteine proteinase involved in bone remodeling and resorption. This protein, which is a member of the peptidase C1 protein family, is predominantly expressed in osteoclasts. However, the encoded protein is also expressed in a significant fraction of human breast cancers, where it could contribute to tumor invasiveness. Mutations in this gene are the cause of pycnodysostosis, an autosomal recessive disease characterized by osteosclerosis and short stature.

Réactivité croisée (Details): Human.

Purification: 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.

Immunogène: Recombinant fragment of human Cathepsin K protein (around aa 163-274) (exact sequence is proprietary)

Isotype: IgG1 kappa

Information d'application

Indications d'application:

Known_Application: Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT) (Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes), Optimal dilution for a specific application should be determined.

Positive_Control: Human liver or breast tissue (IHC).

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: Prepared in 10 mM PBS, WITHOUT BSA and Azide.

Agent conservateur: Azide free

Stock: -20 °C,-80 °C

Stockage commentaire: Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.

Date de péremption: 24 months

Détails sur Cathepsin K

Antigène: Cathepsin K (CTSK)

Autre désignation: CTSK

Sujet: Cathepsin K, Cathepsin O, Cathepsin O1, Cathepsin O2, Cathepsin X, CTS02, Ctsk, CTSO1, CTSO2, PKND, PYCD,Cathepsin K (Marker of Tumor Invasiveness)
Cellular localisation: Cytoplasmic

Poids moléculaire: 39kDa

ID gène: 1513, 632466

UniProt: P43235

Pathways: Activation of Innate immune Response, Toll-Like Receptors Cascades