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Desmocollin 2 anticorps (Extracellular Domain)

DSC2 Reactivité: Humain WB, IF, FACS, IHC (f) Hôte: Souris Monoclonal 7G6 unconjugated
N° du produit ABIN6937104
  • Antigène Voir toutes Desmocollin 2 (DSC2) Anticorps
    Desmocollin 2 (DSC2)
    Épitope
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Extracellular Domain
    Reactivité
    • 28
    • 7
    • 4
    Humain
    Hôte
    • 18
    • 10
    • 2
    Souris
    Clonalité
    • 22
    • 8
    Monoclonal
    Conjugué
    • 23
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp Desmocollin 2 est non-conjugé
    Application
    • 17
    • 11
    • 9
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF), Flow Cytometry (FACS), Immunohistochemistry (Formalin-fixed Sections) (IHC (f))
    Specificité
    Desmosomes are intercellular adhering junctions that represent cell surface attachment sites for intermediate filament. The desmosome is subdivided into two regions. The plaque region lies adjacent to the plasma, and is believed to contain molecules that attach the intermediate filament cytoskeleton to the desmosome. The core region is composed of transmembrane glycoproteins that are thought to mediate cell-cell adhesion. Desmogleins and desmocollins are the main desmosomal transmembrane proteins. These desmosomal glycoproteins belong to the members of the cadherin family of adhesion molecules. Three different isoforms of both desmogleins and desmocollins have been identified, named as desmoglein 1-3 and desmocollins. Desmosomal cadherins showed differentiation-specific expression in the human epidermis, although the functional significance of this differential expression is not fully understood. Desmocollin-1 can be found in the upper layers. The expression of desmocollin-2 varies in the basal and suprabasal layers. And desmocollin-3 is expressed more evenly throughout the suprabasal layers.
    Réactivité croisée (Details)
    Human. Mouse. Rat.
    Purification
    1.0mg/ml of Ab purified from Bioreactor by Protein A/G.
    Immunogène
    Human desmocollin-2 extracellular domain
    Clone
    7G6
    Isotype
    IgG1 kappa
    Top Product
    Discover our top product DSC2 Anticorps primaire
  • Indications d'application

    Known_Application: Flow Cytometry (1-2 μg/million cells), Immunofluorescence (1-2 μg/mL), Western Blot (1-2 μg/mL), Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes)Optimal dilution for a specific application should be determined.

    Positive_Control: HeLa cells. Skin tissue.

    Restrictions
    For Research Use only
  • Concentration
    1.0 mg/mL
    Buffer
    Prepared in 10 mM PBS, WITHOUT BSA and Azide.
    Agent conservateur
    Azide free
    Stock
    -20 °C,-80 °C
    Stockage commentaire
    Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.
    Date de péremption
    24 months
  • Antigène
    Desmocollin 2 (DSC2)
    Autre désignation
    DSC2 (DSC2 Produits)
    Synonymes
    anticorps ARVD11, anticorps CDHF2, anticorps DG2, anticorps DGII/III, anticorps DSC3, anticorps AW228162, anticorps Dsc2a, anticorps Dsc2b, anticorps DSC2, anticorps desmocollin 2, anticorps DSC2, anticorps Dsc2
    Sujet
    ARVD11, Cadherin family member 2, CDHF2, Desmocollin-2, Desmocollin-3, Desmosomal glycoprotein II and III, Desmosomal glycoprotein II, Desmosomal glycoprotein III, DG2, DGII/III, DSC2, DSC3,Desmocollin-2/3
    Cellular localisation: Cell surface
    Poids moléculaire
    110kDa (DSC2), 100kDa (DSC3)
    ID gène
    1824, 95612
    UniProt
    Q02487
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