Desmoglein 1 anticorps (Intracellular)

N° du produit ABIN6937106

Cet anticorps Souris Monoclonal détecte spécifiquement Desmoglein 1 dans WB, IF et FACS. Il présente une réactivité envers Humain.

Aperçu rapide pour Desmoglein 1 anticorps (Intracellular) (ABIN6937106)

Antigène: Desmoglein 1 (DSG1)

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Desmoglein 1 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Flow Cytometry (FACS)

Clone: 18D4

Détail du produit anti-Desmoglein 1 anticorps

Épitope: Intracellular

Specificité: Recognizes a protein of ~150 kDa, identified as Desmoglein-1 (DSG1). Desmoglein-1 is a member of the desmosomal cadherin family.Desmosomes are intercellular adhering junctions that represent cell surface attachment sites for intermediate filament. Desmocollins and desmogleins are the main desmosomal transmembrane proteins. Desmogleins consist of Dsg1, Dsg2, Dsg3, and Dsg4 isoforms.Within the desmosome, the extracellular domain of desmoglein is essential for calcium dependent heterophilic binding to the desmocollins, whereas the intracellular domain is essential for binding to the desmosomal plaque protein, plakoglobin. Desmoglein 1 is synthesized exclusively in the suprabasal layers. Intact and functionally active desmoglein 1 is essential to epidermal integrity.

Réactivité croisée (Details): Human.

Purification: 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.

Immunogène: Human desmoglein-1 intracellular domain

Isotype: IgG1 kappa

Information d'application

Indications d'application:

Known_Application: Flow Cytometry (1-2 μg/million cells), Immunofluorescence (1-2 μg/mL), Western Blot (1-2 μg/mL) Optimal dilution for a specific application should be determined.

Positive_Control: A431 or A-375 cells. Skin.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: Prepared in 10 mM PBS, WITHOUT BSA and Azide.

Agent conservateur: Azide free

Stock: -20 °C,-80 °C

Stockage commentaire: Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.

Date de péremption: 24 months

Détails sur Desmoglein 1

Antigène: Desmoglein 1 (DSG1)

Autre désignation: DSG1

Sujet: Cadherin family member 4, CDHF4, Desmoglein-1, Desmosomal glycoprotein 1, DG1, DSG1, EPKHE, EPKHIA, Pemphigus foliaceus antigen, PPKS1, SPPK1,Desmoglein-1 (DSG1)
Cellular localisation: Cell surface

Poids moléculaire: 150kDa (precursor), 160kDa (mature)

ID gène: 1828, 2633

UniProt: Q02413

Pathways: Cell-Cell Junction Organization