ESR2 anticorps
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- Antigène Voir toutes ESR2 Anticorps
- ESR2 (Estrogen Receptor 2 (ESR2))
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Reactivité
- Humain
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Hôte
- Souris
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Clonalité
- Monoclonal
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Conjugué
- Cet anticorp ESR2 est non-conjugé
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Application
- ELISA, Immunohistochemistry (IHC), Coating (Coat)
- Specificité
- Estrogen receptors (ER) are members of the steroid/thyroid hormone receptor superfamily of ligand-activated transcription factors. Estrogen receptors, including ER-alpha and ER-beta, contain DNA binding and ligand binding domains and are critically involved in regulating the normal function of reproductive tissues. They are located in the nucleus, though some estrogen receptors associate with the cell surface membrane and can be rapidly activated by exposure of cells to estrogen. ER-alpha and ER-beta are differentially activated by various ligands. Receptor-ligand interactions trigger a cascade of events, including dissociation from heat shock proteins, receptor dimerization, phosphorylation and the association of the hormone activated receptor with specific regulatory elements in target genes. Evidence suggests that ER-alpha and ER-beta may be regulated by distinct mechanisms even though they share many functional characteristics.
- Réactivité croisée (Details)
- Human.
- Purification
- 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.
- Immunogène
- Recombinant full-length human ESR2 protein
- Clone
- ESR2-3207
- Isotype
- IgG2b kappa
- Top Product
- Discover our top product ESR2 Anticorps primaire
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- Indications d'application
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Known_Application: ELISA (For coating, order Ab without BSA), Optimal dilution for a specific application should be determined.
Positive_Control: Ovarian, breast, bladder, gastric or salivary carcinoma (IHC).
- Restrictions
- For Research Use only
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- Concentration
- 1.0 mg/mL
- Buffer
- Prepared in 10 mM PBS, WITHOUT BSA and Azide.
- Agent conservateur
- Azide free
- Stock
- -20 °C,-80 °C
- Stockage commentaire
- Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.
- Date de péremption
- 24 months
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- Antigène
- ESR2 (Estrogen Receptor 2 (ESR2))
- Autre désignation
- ESR2 (ESR2 Produits)
- Synonymes
- anticorps ER-BETA, anticorps ESR-BETA, anticorps ESRB, anticorps ESTRB, anticorps Erb, anticorps NR3A2, anticorps ER[b]1, anticorps zfER-beta1, anticorps zfER[b]1, anticorps erb2, anticorps CERB, anticorps ERB, anticorps erb, anticorps esrb, anticorps estrb, anticorps nr3a2, anticorps ERbeta, anticorps er-beta, anticorps esr-beta, anticorps ESR2, anticorps ERBETA, anticorps er, anticorps ER-beta, anticorps ER[b], anticorps Estrb, anticorps ER[b]2, anticorps ER[b]a, anticorps zfER[b]2, anticorps zfER-beta2, anticorps Erb2, anticorps esr2, anticorps erbeta, anticorps Esr2, anticorps ERBeta2, anticorps estrogen receptor 2, anticorps estrogen receptor 2b, anticorps estrogen receptor beta 2, anticorps estrogen receptor 2 (beta), anticorps estrogen receptor 2a, anticorps estrogen receptor beta, anticorps ESR2, anticorps esr2b, anticorps erb2, anticorps esr2, anticorps Esr2, anticorps esr2a, anticorps erbeta
- Sujet
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Erb, ESR BETA, ESR2, ESRB, ESTRB, estrogen nuclear receptor beta variant a, estrogen nuclear receptor beta variant b, estrogen receptor 2 (ER beta), estrogen receptor beta 4,ER-beta-1 (Estrogen Receptor beta-1)
Cellular localisation: Predominantly nuclear - Poids moléculaire
- 53-59kDa
- ID gène
- 2100, 660607
- UniProt
- Q92731
- Pathways
- Nuclear Receptor Transcription Pathway, EGFR Signaling Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Steroid Hormone Mediated Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling
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