FOXA1 anticorps (AA 372-472)

N° du produit ABIN6937254

Détail du produit anti-FOXA1 anticorps

Antigène: FOXA1 (Forkhead Box A1 (FOXA1))

Épitope: AA 372-472

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp FOXA1 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Flow Cytometry (FACS), Immunostaining (ISt), Immunohistochemistry (Formalin-fixed Sections) (IHC (f))

Specificité: The transcription factor Forkhead-box A1 (FOXA1), also known as hepatocyte nuclear factor 3-alpha, is a member of the FOX class of transcription factors.HNF-1 (), and HNF-6 compose, in part, a homeoprotein family designated the hepatocyte nuclear factor family. The various HNF-1 isoforms regulate transcription of genes in the liver as well as in other tissues such as kidney, small intestine and thymus. FOXA1 is expressed in normal breast ductal epithelium and other epithelium in different organs, such as lung, pancreas, bladder, prostate, and colon. Recently, FOXA1 has been shown to be a major determinant of estrogen-ER activity and endocrine response in breast cancer cells. FOXA1 expression correlates with estrogen receptor (ER)-positivity, especially in luminal subtype A breast cancers, which is associated with favorable prognosis. FOXA1 is useful in the sub-classification of breast carcinomas.

Aucune reactivité croisée: Rat (Rattus)

Réactivité croisée (Details): Human. Does not react with Rat.

Purification: 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.

Immunogène: Recombinant human FOXA1 protein fragment (aa372-472) (exact sequence is proprietary)

Clone: FOXA1-1512

Isotype: IgG1 kappa

Information d'application

Indications d'application:

Known_Application: Flow Cytometry (1-2 μg/million cells), Immunofluorescence (1-2 μg/mL), Western Blot (1-2 μg/mL), Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT) (Staining of formalin-fixed tissues is enhanced by heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0 for 45 min at 95°C followed by cooling at RT for 20 minutes),Optimal dilution for a specific application should be determined.

Positive_Control: HeLa, PC3, HepG-2 or MCF-7 cells. Human liver, pancreas or prostate tissue.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: Prepared in 10 mM PBS, WITHOUT BSA and Azide.

Agent conservateur: Azide free

Stock: -20 °C,-80 °C

Stockage commentaire: Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.

Date de péremption: 24 months

Détails sur FOXA1

Antigène: FOXA1 (Forkhead Box A1 (FOXA1))

Autre désignation: FOXA1 (FOXA1 Produits)

Synonymes: anticorps HNF3A, anticorps TCF3A, anticorps Hnf-3a, anticorps Hnf3a, anticorps Tcf-3a, anticorps Tcf3a, anticorps fkd7, anticorps forkhead-7, anticorps HNF3-alpha, anticorps HNF3alpha, anticorps fkh2, anticorps foxa1, anticorps hnf3a, anticorps tFoxA1, anticorps tcf3a, anticorps xfkh2, anticorps fkh, anticorps FOXA1, anticorps Ci-fkh, anticorps HNF-3a, anticorps forkhead box A1, anticorps forkhead box A1 S homeolog, anticorps forkhead homolog, anticorps forkhead box A1 L homeolog, anticorps FOXA1, anticorps Foxa1, anticorps foxa1, anticorps foxa1.S, anticorps fkh, anticorps foxa1.L

Sujet: Forkhead box protein A1 (FOXA1), Hepatocyte nuclear factor 3-alpha (HNF-3-alpha or HNF-3A or HNF3A), Transcription factor 3A (TCF-3A or TCF3A),FOXA1 / HNF3A
Cellular localisation: Nuclear

Poids moléculaire: 49kDa

ID gène: 3169, 163484

UniProt: P55317

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Carbohydrate Homeostasis