GPX4 anticorps

N° du produit ABIN6937347

Détail du produit anti-GPX4 anticorps

Antigène: GPX4 (Glutathione Peroxidase 4 (GPX4))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp GPX4 est non-conjugé

Application: ELISA, Immunofluorescence (IF), Flow Cytometry (FACS), Coating (Coat), Immunohistochemistry (Formalin-fixed Sections) (IHC (f))

Specificité: Glutathione Peroxidase 4 (GPX4) stabilizes cell-substratum interactions during early events of melanoma cell spreading on endothelial basement membranes. NG2 may facilitate primary melanoma progression by enhancing the activation of key signaling pathways important for tumor invasion and growth. Threonine 2256 phosphorylation of rat NG2 (threonine 2252 phosphorylation of human NG2) leads to redistribution of NG2 on the surface of astrocytomas, polarization of the cell and a significant increase in cell motility. NG2 acts as a co-receptor for spreading and focal contact formation in association with 1 integrin in malignant melanoma cells. NG2 is present on blood vessels throughout the rat embryo. Microvessels within the rat CNS express NG2 on endothelial cells, and outside the CNS, NG2 is present on smooth muscle cells. NG2 is a novel marker for epidermal stem cells that contributes to their patterned distribution by promoting stem cell clustering.

Réactivité croisée (Details): Human. Mouse. Rat.

Purification: 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.

Immunogène: A 375P cells crude extract

Clone: LHM 2

Isotype: IgG1 kappa

Information d'application

Indications d'application:

Known_Application: ELISA (For coating, order antibody without BSA), Flow Cytometry (1-2 μg/million cells), Immunofluorescence (1-2 μg/mL), Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes), Optimal dilution for a specific application should be determined.

Positive_Control: MCF7 or HepG2 cells. Human brain or malignant melanoma.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: Prepared in 10 mM PBS, WITHOUT BSA and Azide.

Agent conservateur: Azide free

Stock: -20 °C,-80 °C

Stockage commentaire: Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.

Date de péremption: 24 months

Détails sur GPX4

Antigène: GPX4 (Glutathione Peroxidase 4 (GPX4))

Autre désignation: GPX4 (GPX4 Produits)

Synonymes: anticorps GPx-4, anticorps GSHPx-4, anticorps MCSP, anticorps PHGPx, anticorps snGPx, anticorps snPHGPx, anticorps Phgpx, anticorps gpx-4, anticorps snGpx, anticorps cb563, anticorps cb691, anticorps PHGPxa, anticorps sb:cb563, anticorps zgc:92253, anticorps wu:fb82e03, anticorps 1700027O09Rik, anticorps mtPHGPx, anticorps ATGPX4, anticorps F11L15.5, anticorps glutathione peroxidase 4, anticorps GP-GPx4, anticorps glutathione peroxidase 4, anticorps glutathione peroxidase 4a, anticorps GPX4, anticorps Gpx4, anticorps gpx4a

Sujet: Glutathione Peroxidase 4 (GPX4), Melanoma-associated Chondroitin Sulfate Proteoglycan (MCSP), Phospholipid hydroperoxidase (PHGPx), Sperm nucleus glutathione peroxidase (snGPx),GPX4 / MCSP
Cellular localisation: Mitochondrion. Cytoplasm.

Poids moléculaire: 21kDa

ID gène: 2879, 433951

UniProt: P36969