ICOSLG anticorps (AA 23-149)
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- Antigène Voir toutes ICOSLG Anticorps
- ICOSLG (Inducible T-Cell Co-Stimulator Ligand (ICOSLG))
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Épitope
- AA 23-149
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Reactivité
- Humain
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Hôte
- Souris
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Clonalité
- Monoclonal
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Conjugué
- Cet anticorp ICOSLG est non-conjugé
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Application
- ELISA, Coating (Coat), Immunohistochemistry (Formalin-fixed Sections) (IHC (f))
- Specificité
- This MAb recognizes a protein of 36 kDa, identified as ICOS-L. It is a ligand for the ICOS receptor that initiates T and B cell proliferation and cytokine secretion. ICOS-L interactions play an essential role in T cell-dependent B cell activation in peripheral lymphoid organs such as spleen and lymph nodes. ICOS-L protein is present in myeloid leukocytes, and by Northern blot there are 2.4, 3.0, and 7.0 kb transcripts in brain, heart, kidney, and liver, with lower expression in colon and thymus, and a 1.1 kb transcript in leukocytes. Tumor necrosis factor alpha (TNF), granulocyte-macrophage colony-stimulating factor (GM-CSF) and interleukin-4 (IL-4) enhance its expression. LPS-induced up-regulation of ICOS-L is dependent on the MyD88-dependent signaling pathway.
- Réactivité croisée (Details)
- Human.
- Purification
- 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.
- Immunogène
- Recombinant fragment of human ICOSLG (B7RP-1) protein (around aa 23-149) (exact sequence is proprietary)
- Clone
- ICOSL-3260
- Isotype
- IgG2b kappa
- Top Product
- Discover our top product ICOSLG Anticorps primaire
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- Indications d'application
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Known_Application: ELISA (For coating, order antibody without BSA),Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT),(Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes), Optimal dilution for a specific application should be determined.
Positive_Control: HL60, HuT78 and HUVEC cells. Prostate or Colon Carcinoma.
- Restrictions
- For Research Use only
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- Concentration
- 1.0 mg/mL
- Buffer
- Prepared in 10 mM PBS, WITHOUT BSA and Azide.
- Agent conservateur
- Azide free
- Stock
- -20 °C,-80 °C
- Stockage commentaire
- Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.
- Date de péremption
- 24 months
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- Antigène
- ICOSLG (Inducible T-Cell Co-Stimulator Ligand (ICOSLG))
- Autre désignation
- ICOSLG (ICOSLG Produits)
- Synonymes
- anticorps ICOSLG, anticorps AU044799, anticorps B7-H2, anticorps B7RP-1, anticorps B7h, anticorps BG071784, anticorps GI50, anticorps GL50, anticorps GL50-B, anticorps ICOS-L, anticorps Icoslg, anticorps LICOS, anticorps Ly115l, anticorps mKIAA0653, anticorps B7H2, anticorps B7RP1, anticorps CD275, anticorps ICOSL, anticorps Icosl, anticorps RGD1562791, anticorps inducible T-cell costimulator ligand, anticorps icos ligand, anticorps inducible T-cell co-stimulator ligand, anticorps ICOSLG, anticorps Icosl, anticorps Icoslg
- Sujet
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B7 homolog 2 (B7H2), B7 like protein Gl50, B7 related protein 1 (B7RP1), CD275, CD275 antigen, GL50, ICOS LG, ICOS ligand (ICOSL), Inducible T cell co stimulator ligand, LICOS, Transmembrane protein B7 H2 ICOS ligand,ICOS-L / ICOS Ligand / B7RP-1 (Immuno-Oncology Target)
Cellular localisation: Cell Surface - Poids moléculaire
- 36kDa
- ID gène
- 23308, 14155
- UniProt
- O75144
- Pathways
- Production of Molecular Mediator of Immune Response, Activated T Cell Proliferation
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