IgD anticorps

N° du produit ABIN6937493

Détail du produit anti-IgD anticorps

Antigène: IgD

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp IgD est non-conjugé

Application: Flow Cytometry (FACS), Immunofluorescence (IF), Immunohistochemistry (Formalin-fixed Sections) (IHC (f))

Specificité: Immunoglobulins are four-chain, Y-shaped, monomeric structures comprised of two identical heavy chains and two identical light chains held together through interchain disulfide bonds. The chains form two domains, the Fab (antigen binding) fragment and the Fc (constant) fragment. Immunoglobulin D (IgD) exists as a monomer with light chains. It plays a biological role as a transmembrane receptor molecule, co-expressed with IgM on the surface of mature/naive B cells. In particular, it is found on spleen B cell surfaces. Compared to IgM, IgD exists in much lower numbers and is not expressed on immature B cells. IgD surface expression on B cells is regulated in part by IL-27. In mice, the inhibition of this immunoglobulin isotype does not cause a significant change to the immune system.

Réactivité croisée (Details): Human.

Purification: 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.

Immunogène: Full-length human IGHD protein

Clone: IgD26

Isotype: IgG1 kappa

Information d'application

Indications d'application:

Known_Application: Flow Cytometry (1-2 μg/million cells), Immunofluorescence (1-2 μg/mL), Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 1 mM EDTA buffer, pH 7.5-8.5, for 45 min at 95°C followed by cooling at RT for 20 minutes)Optimal dilution for a specific application should be determined.

Positive_Control: Human tonsil lysate, NAMALWA cell lysate, Human tonsil and lymphoid tissues.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: Prepared in 10 mM PBS, WITHOUT BSA and Azide.

Agent conservateur: Azide free

Stock: -20 °C,-80 °C

Stockage commentaire: Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.

Date de péremption: 24 months

Détails sur IgD

Antigène: IgD

Autre désignation: IGHD (IgD Produits)

Synonymes: anticorps IgD, anticorps Igh-5, anticorps immunoglobulin heavy constant delta, anticorps immunoglobulin delta heavy chain constant region, anticorps Ighd, anticorps Igd, anticorps IGHD

Classe de substances: Antibody

Sujet: Ig delta chain C region, IGHD, Immunoglobulin heavy constant delta,IgD (Immunoglobulin Delta Heavy Chain) (B-Cell Marker)
Cellular localisation: Cytoplasmic

Poids moléculaire: 44-80kDa (heavy chain), 21-25kDa (kappa light chain)

ID gène: 3495, 510635

UniProt: P01880