LHB anticorps
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- Antigène Voir toutes LHB Anticorps
- LHB (Luteinizing Hormone beta Polypeptide (LHB))
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Reactivité
- Humain
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Hôte
- Souris
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Clonalité
- Monoclonal
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Conjugué
- Cet anticorp LHB est non-conjugé
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Application
- Immunohistochemistry (Formalin-fixed Sections) (IHC (f))
- Specificité
- Luteinizing hormone (LH) is a glycoprotein. Each monomeric unit is a sugar-like protein molecule, two of these make the full, functional protein. Its structure is similar to the other glycoproteins, follicle-stimulating hormone (FSH), thyroid-stimulating hormone (TSH), and human chorionic gonadotropin (hCG). The protein dimer contains 2 polypeptide units, labeled alpha and beta subunits that are connected by two bridges. The alpha subunits of LH, FSH, TSH, and hCG are identical, and contain 92 amino acids. The beta subunits vary. LH has a beta subunit of 121 amino acids (LHB) that confers its specific biologic action and is responsible for interaction with the LH receptor. This beta subunit contains the same amino acids in sequence as the beta subunit of hCG and both stimulate the same receptor, however, the hCG beta subunit contains an additional 24 amino acids and the hormones differ in the composition of their sugar moieties.LH is synthesized and secreted by gonadotrophs in the anterior lobe of the pituitary gland. In concert with the other pituitary gonadotropin follicle-stimulating hormone (FSH), it is necessary for proper reproductive function. In the female, an acute rise of LH levels triggers ovulation. In the male, where LH has also been called Interstitial Cell-Stimulating Hormone (ICSH), it stimulates Leydig cell production of testosterone. LH is a useful marker in classification of pituitary tumors and the study of pituitary disease.
- Réactivité croisée (Details)
- Human.
- Purification
- 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.
- Immunogène
- Recombinant beta sub-unit of human LH
- Clone
- LHb-1214
- Isotype
- IgG1 kappa
- Top Product
- Discover our top product LHB Anticorps primaire
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- Indications d'application
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Known_Application: Immunohistochemistry (Formalin-fixed) (1-2 μg/mL, 30 min RT) (Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes), Optimal dilution for a specific application should be determined.
Positive_Control: Anterior Pituitary.
- Restrictions
- For Research Use only
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- Concentration
- 1.0 mg/mL
- Buffer
- Prepared in 10 mM PBS, WITHOUT BSA and Azide.
- Agent conservateur
- Azide free
- Stock
- -20 °C,-80 °C
- Stockage commentaire
- Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.
- Date de péremption
- 24 months
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- Antigène
- LHB (Luteinizing Hormone beta Polypeptide (LHB))
- Autre désignation
- LHB (LHB Produits)
- Synonymes
- anticorps CGB4, anticorps LSH-B, anticorps hLHB, anticorps LH, anticorps LH-B, anticorps LSH-beta, anticorps cgb4, anticorps hlhb, anticorps xlhb, anticorps lhb-A, anticorps lsh-b, anticorps LH/CG-beta, anticorps LHB, anticorps LSH-B/CG-B, anticorps Lutropin beta chain, anticorps lhb1, anticorps lhbeta1, anticorps zgc:92312, anticorps lhb, anticorps luteinizing hormone beta polypeptide, anticorps luteinizing hormone beta, anticorps lutropin subunit beta-like, anticorps luteinizing hormone, beta polypeptide, anticorps luteinizing hormone beta polypeptide L homeolog, anticorps LHB, anticorps Lhb, anticorps lhb, anticorps LOC106838274, anticorps lhb.L
- Sujet
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Chorionic Gonadotropin, Beta polypeptide 4 (CGB4), hLHB, Interstitial cell stimulating hormone beta chain, Leutropin, LH-B, LHB, LSH-B, LSH-beta, Luteinizing hormone beta polypeptide, Lutropin beta chain,LH-beta (Luteinizing Hormone-beta)
Cellular localisation: Cytoplasmic, secreted - Poids moléculaire
- 22kDa
- ID gène
- 3972, 154704
- UniProt
- P01229
- Pathways
- Metabolism of Steroid Hormones and Vitamin D, Peptide Hormone Metabolism, Hormone Activity, C21-Steroid Hormone Metabolic Process
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