LSP1 anticorps (AA 174-278)

N° du produit ABIN6937790

Cet anticorps Souris Monoclonal détecte spécifiquement LSP1 dans IHC (p) et IHC (f). Il présente une réactivité envers Humain.

Aperçu rapide pour LSP1 anticorps (AA 174-278) (ABIN6937790)

Antigène: LSP1 (Lymphocyte-Specific Protein 1 (LSP1))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp LSP1 est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Formalin-fixed Sections) (IHC (f))

Clone: LSP1-3025

Détail du produit anti-LSP1 anticorps

Épitope: AA 174-278

Specificité: LSP1 is a hematopoietic-expressed gene that encodes an F-actin-binding, leukocyte-specific (including B and T lymphocytes, granulocytes and macrophages), phosphoprotein. However, mRNA splice variants that do not encode the lympho-specific protein are expressed from this gene in nonlymphoid cell lines as well (myocytes, stromal cells and fibroblasts), suggesting pp52 has a divergent role in signal transduction. The pp52 (LSP1) locus maps to human chromosome 11p15.5, which is implicated in tumor-related chromosomal translocations found in chronic lymphocytic leukemia. The pp52 promoter contains key elements that control transcriptional activity including an initiator specifying the unique 5' terminus of pp52 mRNA, tandem pairs of Ets and SP1 motifs, and a single C/EBP motif. LSP1 binds the cytoskeleton and has been implicated in affecting cytoskeletal remodeling in a variety of leukocyte functions, including cell motility and chemotaxis.

Réactivité croisée (Details): Human.

Purification: 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.

Immunogène: Recombinant fragment of human LSP1 protein (around aa174-278) (exact sequence is proprietary)

Isotype: IgG1 kappa

Information d'application

Indications d'application:

Known_Application: Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 minutes at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes)Optimal dilution for a specific application should be determined.

Positive_Control: Human tonsil, colon, spleen or Hodgkin's lymphoma (IHC-P).

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: Prepared in 10 mM PBS, WITHOUT BSA and Azide.

Agent conservateur: Azide free

Stock: -20 °C,-80 °C

Stockage commentaire: Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.

Date de péremption: 24 months

Détails sur LSP1

Antigène: LSP1 (Lymphocyte-Specific Protein 1 (LSP1))

Autre désignation: LSP1

Sujet: WP34, pp52, lymphocyte specific protein 1, leukocyte specific protein 1,Lymphocyte Specific Protein 1 (LSP1) / pp52
Cellular localisation: Membrane.

Poids moléculaire: 52kDa

ID gène: 4046, 56729

UniProt: P33241