MMP3 anticorps

N° du produit ABIN6937883

Détail du produit anti-MMP3 anticorps

Antigène: MMP3 (Matrix Metallopeptidase 3 (Stromelysin 1, Progelatinase) (MMP3))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp MMP3 est non-conjugé

Application: Immunohistochemistry (Formalin-fixed Sections) (IHC (f))

Specificité: The matrix metalloproteinases (MMP) are a family of peptidase enzymes responsible for the degradation of extracellular matrix components, including collagen, gelatin, fibronectin, laminin and proteoglycan. Transcription of MMP genes is differentially activated by phorbol ester, lipopolysaccharide (LPS) or staphylococcal enterotoxin B (SEB). MMP catalysis requires both calcium and zinc. MMP-3, MMP-10 and MMP-11 (also designated stromelysin-1, 2 and 3, respectively) activate procollagenase. MMP-3 activation of procollagenase can occur via two pathways. Direct activation by MMP-3 is slow and activation by MMP-3 in conjunction with tissue or plasma proteinases is rapid. MMP-10 is expressed in small intestine, and at lower levels in lung and heart. MMP-11 is specifically expressed in stromal cells of breast carcinomas and contributes to epithelial cell malignancies.

Réactivité croisée (Details): Human.

Purification: 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.

Immunogène: Recombinant full-length human MMP3 protein

Clone: MMP3-2806

Isotype: IgG2c kappa

Information d'application

Indications d'application:

Known_Application: Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT),(Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95 °C followed by cooling at RT for 20 minutes),Optimal dilution for a specific application should be determined.

Positive_Control: A431 cells. Human prostate or lung carcinoma

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: Prepared in 10 mM PBS, WITHOUT BSA and Azide.

Agent conservateur: Azide free

Stock: -20 °C,-80 °C

Stockage commentaire: Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.

Date de péremption: 24 months

Détails sur MMP3

Antigène: MMP3 (Matrix Metallopeptidase 3 (Stromelysin 1, Progelatinase) (MMP3))

Autre désignation: MMP3 (MMP3 Produits)

Synonymes: anticorps CHDS6, anticorps MMP-3, anticorps SL-1, anticorps STMY, anticorps STMY1, anticorps STR1, anticorps SLN-1, anticorps SLN1, anticorps STR-1, anticorps Stmy1, anticorps Str1, anticorps MMP10, anticorps chds6, anticorps mmp-3, anticorps mmp13, anticorps mmp3, anticorps sl-1, anticorps stmy, anticorps stmy1, anticorps str1, anticorps matrix metallopeptidase 3, anticorps matrix metallopeptidase 3 (stromelysin 1, progelatinase), anticorps matrix metallopeptidase 3 L homeolog, anticorps MMP3, anticorps Mmp3, anticorps mmp3.L

Sujet: CHDS6, Matrix metalloproteinase 3, Matrix metalloproteinase-3, MMP3, Proteoglycanase, SL1, STMY1, STR1, Stromelysin-1, Transin 1,MMP3 (Marker of Metastasis and Rheumatoid Arthritis)
Cellular localisation: Cytoplasm. Extracellular Matrix.

Poids moléculaire: 57kDa

ID gène: 4314, 375129

UniProt: P08254