Nkx2-2 anticorps (AA 1-119)
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- Antigène Voir toutes Nkx2-2 Anticorps
- Nkx2-2 (NK2 Homeobox 2 (Nkx2-2))
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Épitope
- AA 1-119
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Reactivité
- Humain
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Hôte
- Souris
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Clonalité
- Monoclonal
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Conjugué
- Cet anticorp Nkx2-2 est non-conjugé
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Application
- Immunohistochemistry (Formalin-fixed Sections) (IHC (f))
- Specificité
- Expression of NKX2.2 has been found in neuroendocrine tumors of the gut, making it a potential marker for the study of gastrointestinal neuroendocrine tumors. More recently, NKX2.2 protein was identified as a target of EWS-FLI-1, the fusion protein specific to Ewing sarcoma, and was shown to be differentially upregulated in Ewing sarcoma on the basis of array-based gene expression analysis. It acts as a valuable marker for Ewing sarcoma, with a sensitivity of 93 % and a specificity of 89 %, and aids in the differential diagnosis of small round cell tumors.
- Réactivité croisée (Details)
- Human.
- Purification
- 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.
- Immunogène
- Recombinant fragment (around aa1-119) of human NKX2.2 protein (exact sequence is proprietary)
- Clone
- NX2-1523
- Isotype
- IgG1 kappa
- Top Product
- Discover our top product Nkx2-2 Anticorps primaire
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- Indications d'application
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Known_Application: Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 minutes at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes); Optimal dilution for a specific application should be determined.
Positive_Control: Pancreas or Ewing's Sarcoma.
- Restrictions
- For Research Use only
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- Concentration
- 1.0 mg/mL
- Buffer
- Prepared in 10 mM PBS, WITHOUT BSA and Azide.
- Agent conservateur
- Azide free
- Stock
- -20 °C,-80 °C
- Stockage commentaire
- Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.
- Date de péremption
- 24 months
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- Antigène
- Nkx2-2 (NK2 Homeobox 2 (Nkx2-2))
- Autre désignation
- NKX2-2 (Nkx2-2 Produits)
- Synonymes
- anticorps XeNK-2, anticorps Xnkx2.2, anticorps nkx2-2-A, anticorps nkx2.2, anticorps NKX-2.2, anticorps NKX2.2, anticorps NKX2B, anticorps Nkx-2.2, anticorps Nkx2.2, anticorps tinman, anticorps id:ibd5090, anticorps nk2.2, anticorps nkx2-2, anticorps wu:fc83b01, anticorps zgc:136536, anticorps NK2 homeobox 2 S homeolog, anticorps NK2 homeobox 2, anticorps NK2 homeobox 2a, anticorps nkx2-2.S, anticorps NKX2-2, anticorps Nkx2-2, anticorps nkx2.2a
- Sujet
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Homeobox protein NK-2 homolog B, NK2 transcription factor like protein B, NK2 transcription factor related locus 2, NKX22, Nkx2b, tinman,NKX2.2 (Neuroendocrine & Ewing's Sarcoma Marker)
Cellular localisation: Nuclear - Poids moléculaire
- 40-50kDa
- ID gène
- 4821, 516922
- UniProt
- O95096
- Pathways
- Dopaminergic Neurogenesis
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