Tel:
+49 (0)241 95 163 153
Fax:
+49 (0)241 95 163 155
E-Mail:
orders@anticorps-enligne.fr

NKX6-1 anticorps

NKX6-1 Reactivité: Humain IHC (f) Hôte: Souris Monoclonal NKX61-2561 unconjugated
N° du produit ABIN6938077
  • Antigène Voir toutes NKX6-1 Anticorps
    NKX6-1 (NK6 Homeobox 1 (NKX6-1))
    Reactivité
    • 44
    • 24
    • 12
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Humain
    Hôte
    • 37
    • 6
    • 1
    • 1
    Souris
    Clonalité
    • 39
    • 6
    Monoclonal
    Conjugué
    • 26
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp NKX6-1 est non-conjugé
    Application
    • 35
    • 24
    • 7
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Immunohistochemistry (Formalin-fixed Sections) (IHC (f))
    Specificité
    Members of the Nkx family of homeodomain proteins are key regulators of growth and development in several tissues, including brain, heart and pancreas. During neural development, sonic hedgehog (Shh) is known to control cell fate and mitogenesis, which is correlated with Shh dose-dependent expression of several genes, including Nkx-6.1. Specifically, Nkx-6.1 is responsible for cellular differentiation in the ventral neural tube and spinal meninges in response to Shh. In the pancreas, Nkx-6.1 is exclusively expressed in the islets of Langerhans in differentiating and mature B cells, which produce Insulin. The presence of Pdx-1 is required for the expression of Nkx-6.1 as well as other pancreatic B cell specific genes, including Insulin, Glut2 and IAPP. Subsequently, Nkx-6.1 binds to the DNA consensus sequence, TTAATTAC, to direct the repression of specific genes in B cells. Nkx6.1 is highly expressed in pancreatic and duodenal well-differentiated neuroendocrine tumors (WDNETS) and in metastatic WDNETS, is a highly specific marker of tumors of pancreatic origin. It has thus been suggested that Nkx6.1 is a useful inclusion into IHC panels for identifying primary sites of WDNETS.
    Réactivité croisée (Details)
    Human.
    Purification
    1.0mg/ml of Ab purified from Bioreactor by Protein A/G.
    Immunogène
    Recombinant full-length human NKX6.1 protein
    Clone
    NKX61-2561
    Isotype
    IgG2c kappa
    Top Product
    Discover our top product NKX6-1 Anticorps primaire
  • Indications d'application

    Known_Application: Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT),(Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes), Optimal dilution for a specific application should be determined.

    Positive_Control: Human fetal small intestine lysate or pancreas tissue.

    Restrictions
    For Research Use only
  • Concentration
    1.0 mg/mL
    Buffer
    Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
    Agent conservateur
    Azide free
    Stock
    -20 °C,-80 °C
    Stockage commentaire
    Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.
    Date de péremption
    24 months
  • Antigène
    NKX6-1 (NK6 Homeobox 1 (NKX6-1))
    Autre désignation
    NKX6-1 (NKX6-1 Produits)
    Synonymes
    anticorps nkx6a, anticorps nkx6.1, anticorps NKX6.1, anticorps NKX6A, anticorps zgc:92879, anticorps Nkx6.1, anticorps Nkx61, anticorps Nkx6a, anticorps NK6 homeobox 1, anticorps NK6 homeobox 1 L homeolog, anticorps nkx6-1, anticorps NKX6-1, anticorps nkx6.1, anticorps nkx6-1.L, anticorps Nkx6-1
    Sujet
    Homeobox protein NK-6 homolog A, NK homeobox, family 6, A, NK6 homeobox 1, NK6 transcription factor homolog A, NK6 transcription factor related, locus 1 (Drosophila), NKX6-1, NKX6A,NKX6.1 (Marker for Pancreatic and Duodenal Neuroendocrine Tumors)
    Cellular localisation: Nuclear
    Poids moléculaire
    40-50kDa
    ID gène
    4825, 546270
    UniProt
    P78426
    Pathways
    Dopaminergic Neurogenesis, Positive Regulation of Peptide Hormone Secretion
Vous êtes ici:
Support technique