Spastin anticorps

N° du produit ABIN6938422

Détail du produit anti-Spastin anticorps

Antigène: Spastin (SPAST)

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Spastin est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Coating (Coat), Immunohistochemistry (Formalin-fixed Sections) (IHC (f))

Specificité: The AAA protein family members share an ATPase domain and have roles in various cellular processes including intracellular motility, membrane trafficking, proteolysis, protein folding and organelle biogenesis. Spastin, a member of the AAA protein family, is a 616 amino acid protein and is involved in the function or assembly of nuclear protein complexes. The Spastin protein is expressed ubiquitously and localizes to the nucleus and the cytoplasm, where it may also be involved in microtubule dynamics. Mutations in the Spastin gene (SPAST, SPG4) cause the most common form of spastic paraplegia 4, an autosomal dominant form of hereditary spastic paraplegia (HSP). HSPs comprise a group of inherited neurological disorders characterized by spastic lower extremity weakness due to a length-dependent, retrograde axonopathy of corticospinal motor neurons. SPAST-specific mutations account for approximately 40 % of all autosomal dominant HSPs.

Réactivité croisée (Details): Human. Mouse. Rat.

Purification: 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.

Immunogène: Recombinant full-length human Spastin protein.

Clone: Sp 3G11-1

Isotype: IgG2a kappa

Information d'application

Indications d'application:

Known_Application: ELISA (For coating, order antibody without BSA), Immunofluorescence (1-2 μg/mL), Western Blot (1-2 μg/mL), Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes), Optimal dilution for a specific application should be determined.

Positive_Control: HeLa cells. Rat brain extract.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: Prepared in 10 mM PBS, WITHOUT BSA and Azide.

Agent conservateur: Azide free

Stock: -20 °C,-80 °C

Stockage commentaire: Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.

Date de péremption: 24 months

Détails sur Spastin

Antigène: Spastin (SPAST)

Autre désignation: SPAST (SPAST Produits)

Synonymes: anticorps CG5977, anticorps D-spastin, anticorps Dmel\\CG5977, anticorps Dspastin, anticorps Spas, anticorps zgc:85952, anticorps SPAST, anticorps spg4, anticorps LOC100224472, anticorps ADPSP, anticorps FSP2, anticorps SPG4, anticorps Spg4, anticorps mKIAA1083, anticorps spastin, anticorps spastin S homeolog, anticorps spas, anticorps spast, anticorps SPAST, anticorps Spast, anticorps spast.S

Sujet: ADPSP, FSP2, Spast, Spatin, SPG4,Spastin
Cellular localisation: Cell Membrane and Secreted.

Poids moléculaire: 52kDa

ID gène: 6683, 468091

Pathways: Dynamique des Microtubules, M Phase, Regulation of Cell Size