SPTAN1 anticorps (AA 2351-2475)

N° du produit ABIN6938441

Cet anticorps Souris Monoclonal détecte spécifiquement SPTAN1 dans IHC. Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour SPTAN1 anticorps (AA 2351-2475) (ABIN6938441)

Antigène: SPTAN1 (Spectrin alpha Chain, Brain (SPTAN1))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp SPTAN1 est non-conjugé

Application: Immunohistochemistry (IHC)

Clone: SPTAN1-3352

Détail du produit anti-SPTAN1 anticorps

Épitope: AA 2351-2475

Fonction: Fodrin / Alpha Spectrin II (SPTAN1) / NEAS Antibody

Specificité: Spectrin, an actin binding protein that is a major component of the cytoskeletal superstructure of the erythrocyte plasma membrane, is essential in determining the properties of the membrane including its shape and deformability. Spectrins function as membrane organizers and stabilizers, composed of nonhomologous °™ and æ chains, which aggregate side-to-side in an antiparallel fashion to form dimers, tetramers, and higher polymers. Spectrin °™ I and spectrin æ I are present in erythrocytes, whereas spectrin °™ II (also designated fodrin °™) and spectrin æ II (also designated fodrin æ) are present in other somatic cells. The spectrin tetramers in erythrocytes act as barriers to lateral diffusion, but spectrin dimers seem to lack this function. Activation of calpain results in the breakdown of spectrin °™ II, a neuronal cytoskeleton protein.

Réactivité croisée (Details): Human. Others not known.

Purification: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogène: Recombinant fragment of human SPTAN1 protein (around aa 2351-2475) (exact sequence is proprietary))

Isotype: IgG2c, kappa

Information d'application

Indications d'application:

Known_Application: Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT),(Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes),Optimal dilution for a specific application should be determined.

Positive_Control: Human colon or kidney tissues (IHC).

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: Prepared in 10  mM PBS

Agent conservateur: Azide free

Stock: -20 °C,-80 °C

Stockage commentaire: Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Date de péremption: 24 months

Détails sur SPTAN1

Antigène: SPTAN1 (Spectrin alpha Chain, Brain (SPTAN1))

Autre désignation: SPTAN1

Sujet:

Alpha-II spectrin, brain, EIEE5, Fodrin alpha chain, NEAS, Non erythrocytic spectrin alpha, non-erythroid alpha chain, SPECA, Spectrin alpha chain brain, Spectrin, alpha, non-erythrocytic 1 (alpha-fodrin), Spna2, SPTA2

Human colon or kidney tissues (IHC).

Poids moléculaire: 240kDa

ID gène: 6709, 372331

UniProt: Q13813

Pathways: Caspase Cascade in Apoptosis, Regulation of Actin Filament Polymerization