SUMO2 anticorps
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- Antigène Voir toutes SUMO2 Anticorps
- SUMO2 (Small Ubiquitin Related Modifier 2 (SUMO2))
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Reactivité
- Humain
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Hôte
- Souris
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Clonalité
- Monoclonal
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Conjugué
- Cet anticorp SUMO2 est non-conjugé
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Application
- Immunofluorescence (IF), Flow Cytometry (FACS), Immunohistochemistry (Formalin-fixed Sections) (IHC (f))
- Specificité
- The small ubiquitin-related modifier (SUMO) proteins, which include SUMO-1, 2 and 3, belong to the ubiquitin-like protein family. Like ubiquitin, the SUMO proteins are synthesized as precursor proteins that undergo processing before conjugation to target proteins. Also, both utilize the E1, E2 and E3 cascade enzymes for conjugation. However, SUMO and ubiquitin differ with respect to targeting. Ubiquitination predominantly targets proteins for degradation, whereas sumoylation targets proteins to a variety of cellular processing, including nuclear transport, transcriptional regulation, apoptosis and protein stability. The unconjugated SUMO-1, 2 and 3 proteins localize to the nuclear membrane, nuclear bodies and cytoplasm, respectively. SUMO-1 utilizes Ubc9 for conjugation to several target proteins, which include MDM2, p53, PML and RanGap1. SUMO-2 and 3 contribute to a greater percentage of protein modification than does SUMO-1 and unlike SUMO-1, they can form polymeric chains. In addition, SUMO-3 regulates beta-Amyloid generation and may be critical in the onset or progression of Alzheimer's disease.
- Réactivité croisée (Details)
- Human. Rat. Predicted to show a broad species reactivity.
- Purification
- 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.
- Immunogène
- Recombinant human SUMO2 protein
- Clone
- SUMO2-1199
- Isotype
- IgG1 kappa
- Top Product
- Discover our top product SUMO2 Anticorps primaire
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- Indications d'application
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Known_Application: Flow Cytometry (1-2 μg/million cells), Immunofluorescence (1-2 μg/mL), Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes), Optimal dilution for a specific application should be determined.
Positive_Control: HeLa cells. Breast carcinoma.
- Restrictions
- For Research Use only
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- Concentration
- 1.0 mg/mL
- Buffer
- Prepared in 10 mM PBS, WITHOUT BSA and Azide.
- Agent conservateur
- Azide free
- Stock
- -20 °C,-80 °C
- Stockage commentaire
- Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.
- Date de péremption
- 24 months
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- Antigène
- SUMO2 (Small Ubiquitin Related Modifier 2 (SUMO2))
- Autre désignation
- SUMO2 (SUMO2 Produits)
- Synonymes
- anticorps HSMT3, anticorps SMT3B, anticorps SMT3H2, anticorps SUMO3, anticorps Smt3A, anticorps SMT3A, anticorps SMT3H1, anticorps SUMO-3, anticorps Smt3B, anticorps Smt3h2, anticorps sumo2, anticorps zgc:92241, anticorps SUMO2, anticorps SUMO-2, anticorps Smt3b, anticorps hsmt3, anticorps smt3b, anticorps smt3h2, anticorps sumo-2, anticorps PSMT3, anticorps ATSUMO2, anticorps MCO15.11, anticorps MCO15_11, anticorps SMALL UBIQUITIN-LIKE MODIFIER 2, anticorps SUM2, anticorps SUMO 2, anticorps small ubiquitin-like modifier 2, anticorps small ubiquitin-like modifier 2, anticorps small ubiquitin-like modifier 3, anticorps small ubiquitin-like modifier 2b, anticorps small ubiquitin-related modifier 2, anticorps small ubiquitin-like modifier 2 S homeolog, anticorps small ubiquitin-like modifier 2 L homeolog, anticorps SUMO2, anticorps SUMO3, anticorps Sumo2, anticorps sumo2b, anticorps LOC714892, anticorps sumo2.S, anticorps sumo2.L
- Sujet
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HSMT3, Sentrin 2, Small ubiquitin like modifier 2, Small ubiquitin like modifier protein 3, SMT3A, SMT3B, SMT3 homolog 1 (SMT3H1), SMT3 homolog 2 (SMT3H2), SMT3 homolog, SMT3 suppressor of mif two 3 homolog 1, SMT3 suppressor of mif two 3 homolog 2, SMT3 suppressor of mif two 3 homolog 3, Suppressor of mif two 3 homolog 2, Suppressor of mif two 3 homolog 3, Ubiquitin like protein SMT3A, Ubiquitin like protein SMT3B,SUMO-2
Cellular localisation: Nuclear - Poids moléculaire
- 11-13kDa
- ID gène
- 6613, 474005
- UniProt
- P55854
- Pathways
- Methionine Biosynthetic Process
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